The impact of nanomaterials on autophagy across health and disease conditions

Basit Öğe Kaydı
dc.contributor.authorFlorance, I.
dc.contributor.authorCordani, M.
dc.contributor.authorPashootan, P.
dc.contributor.authorMoosavi, M.A.
dc.contributor.authorZarrabi, A.
dc.contributor.authorChandrasekaran, N.
dc.date.accessioned2024-05-19T14:33:24Z
dc.date.available2024-05-19T14:33:24Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAutophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as a cellular defense response becomes particularly evident upon exposure to nanomaterials (NMs), especially environmental nanoparticles (NPs) and nanoplastics (nPs). This has positioned autophagy modulation at the forefront of nanotechnology-based therapeutic interventions. While NMs can exploit autophagy to enhance therapeutic outcomes, they can also trigger it as a pro-survival response against NP-induced toxicity. Conversely, a heightened autophagy response may also lead to regulated cell death (RCD), in particular autophagic cell death, upon NP exposure. Thus, the relationship between NMs and autophagy exhibits a dual nature with therapeutic and environmental interventions. Recognizing and decoding these intricate patterns are essential for pioneering next-generation autophagy-regulating NMs. This review delves into the present-day therapeutic potential of autophagy-modulating NMs, shedding light on their status in clinical trials, intervention of autophagy in the therapeutic applications of NMs, discusses the potency of autophagy for application as early indicator of NM toxicity. Graphical Abstract: (Figure presented.). © The Author(s) 2024.en_US
dc.description.sponsorshipIndian Council of Medical Research, ICMR: 36/2/2020/Toxi/BMS, RYC2021-031003I, MICIU/AEI/10.13039/501100011033en_US
dc.description.sponsorshipOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. Dr. Natarajan Chandrasekaran and Ms. Ida Florance were supported by ICMR through the Research Grant-F.No 36/2/2020/Toxi/BMS. Dr. Marco Cordani was supported by grant RYC2021-031003I funded by MICIU/AEI/10.13039/501100011033 and, by European Union NextGenerationEU/PRTR. Mohammad A Moosavi is financially supported by the National Institute of Genetic Engineering and Biotechnology, Tehran.en_US
dc.identifier.doi10.1007/s00018-024-05199-y
dc.identifier.issn1420-682X
dc.identifier.issue1en_US
dc.identifier.pmid38630152en_US
dc.identifier.scopus2-s2.0-85190668570en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s00018-024-05199-y
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4217
dc.identifier.volume81en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofCellular and Molecular Life Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAutophagic Fluxen_US
dc.subjectAutophagy Blockadeen_US
dc.subjectEnvironmental Toxicityen_US
dc.subjectNanoparticlesen_US
dc.subjectNanoplasticsen_US
dc.subjectRegulated Cell Deathen_US
dc.titleThe impact of nanomaterials on autophagy across health and disease conditionsen_US
dc.typeReview Articleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Biyomedikal Mühendisliği Bölümü Diğer Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu