Synergistic interactions between resveratrol and doxorubicin inhibit angiogenesis both in vitro and in vivo

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dc.authoridMerve Erkısa Genel / 0000-0002-3127-742X
dc.authorscopusidMerve Erkısa Genel / 57126208900
dc.authorwosidMerve Erkısa Genel / FZJ-0775-2022
dc.contributor.authorUvez, A.
dc.contributor.authorAydınlık, S.
dc.contributor.authorEsener, O. B. B.
dc.contributor.authorErkısa Genel, Merve
dc.contributor.authorKarakuş, D.
dc.contributor.authorArmutak, E.
dc.date.accessioned2021-01-22T08:34:28Z
dc.date.available2021-01-22T08:34:28Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Rektörlüken_US
dc.description.abstractResveratrol is a polyphenolic compound which is found in many nutrients including grapes, peanuts, raspberries, and apples. Anti-proliferative, anti-angiogenic and apoptotic effects of resveratrol have been shown on various cancer cells. Doxorubicin is considered as one of the most effective anticancer agents and reveals its antitumor activity by induction of apoptosis and inhibition of angiogenesis. Our study reports for the first time the potent ability of resveratrol in combination with doxorubicin to inhibit angiogenesis in vitro and in vivo. The cytotoxic effect of resveratrol (1.56-100 mu M), doxorubicin (0.01-0.92 mu M) and their combination were analyzed in the human umbilical vein endothelial cells (HUVECs) by ATP assay. In vitro angiogenesis was evaluated using tube formation assay in HUVECs. In vivo anti-angiogenic activity was assessed in a chick chorioallantoic membrane (CAM) model using fertilized chicken eggs. All test groups were compared to thalidomide as a positive control, three concentrations of resveratrol (10-5-2.5 mu g/pellet) and a 2 mu g/pellet concentration of doxorubicin was examined. All data were evaluated statistically. Resveratrol and doxorubicin alone displayed inhibitory effects on angiogenesis and cell viability at higher doses. However, the combination of resveratrol and doxorubicin exhibited a significant dose-dependent inhibition of CAM angiogenesis in vivo as well as proliferation and tube formation in HUVECs compared to the positive control (+/-)-thalidomide. Our results suggest that resveratrol in combination with doxorubicin is a novel strategy in the prevention and treatment of angiogenesisen_US
dc.identifier.citationUvez, A., Aydinlik, S., Esener, O. B. B., Erkisa, M., Karakus, D., & Armutak, E. I. (2020). Synergistic interactions between resveratrol and doxorubicin inhibit angiogenesis both in vitro and in vivo. Polish Journal of Veterinary Sciences, 571-580.en_US
dc.identifier.doi10.24425/pjvs.2020.135803en_US
dc.identifier.endpage580en_US
dc.identifier.issn1505-1773en_US
dc.identifier.issn2300-2557en_US
dc.identifier.issue4en_US
dc.identifier.pmid33480492en_US
dc.identifier.scopus2-s2.0-85100328107en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage571en_US
dc.identifier.urihttps://doi.org/10.24425/pjvs.2020.135803
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1359
dc.identifier.volume23en_US
dc.identifier.wosWOS:000604955100012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErkısa Genel, Merve
dc.language.isoenen_US
dc.publisherPOLSKA AKAD NAUKen_US
dc.relation.ispartofPOLISH JOURNAL OF VETERINARY SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectResveratrolen_US
dc.subjectChick Chorioallantoic Membrane (CAM) Assayen_US
dc.subjectDoxorubicinen_US
dc.subjectHUVECen_US
dc.subjectTube Formationen_US
dc.subjectAnti-Angiogenic Activityen_US
dc.titleSynergistic interactions between resveratrol and doxorubicin inhibit angiogenesis both in vitro and in vivoen_US
dc.typeArticleen_US

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