MIS-C Treatment: Is glucocorticoid monotherapy enough for mild cases?

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dc.authorscopusidMurat Sütçü / 55499199300
dc.authorscopusidGül Doruk / 57222108765
dc.authorscopusidFunda Yıldız / 57226016668
dc.authorscopusidFatih Atik / 57789999700
dc.authorscopusidOzan Özkaya / 7003365098
dc.authorwosidMurat Sütçü / AAR-5212-2020
dc.authorwosidGül Doruk / AGJ-2448-2022
dc.authorwosidFunda Yıldız / ITJ-7061-2023
dc.authorwosidFatih Atik / FXI-4226-2022
dc.authorwosidOzan Özkaya / DKK-1373-2022
dc.contributor.authorSütçü, Murat
dc.contributor.authorKara, Emine Manolya
dc.contributor.authorYıldız, Funda
dc.contributor.authorGül, Doruk
dc.contributor.authorYıldız, Raif
dc.contributor.authorYılmaz, Duygu
dc.contributor.authorAtik, Fatih
dc.contributor.authorÖzkaya, Ozan
dc.date.accessioned2025-04-18T10:10:42Z
dc.date.available2025-04-18T10:10:42Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground: The effectiveness of using only glucocorticoids (GCs) in mild multisystem in flammatory syndrome (MIS-C) cases was compared with combined treatment [GCs + Intravenous immune globulin (IVIG)]. Methods: This retrospective cohort study was conducted between June 1, 2020, and June 1, 2022, in a tertiary care center in Istanbul, Turkey. Clinical and investigational data of the MIS-C patients were analyzed. The patients were divided into two groups: those who received only GCs and those who received the GCs + IVIG combination. The primary outcome focused on assessing the deterioration of the patient's clinical condition, the occurrence of shock, admission to the pediatric intensive care unit (PICU), and the need for additional immunosuppressive medication. Secondary outcomes included evaluating the course of cardiovascular and infection-related complications observed at the one-year follow-up. Results: Ninety-seven MIS-C patients with a median age of 41 (3 - 214) months were enrolled. Fifty-six (57.7%) patients were male. All the patients had fever at admission with a temperature of 39 degrees C (37.5 degrees C -40.1 degrees C). Thirty-two patients (33%) had cardiac findings on echocardiography [left ventricular dysfunction ( n = 13, 13.5%), coronary artery involvement ( n = 11, 11.3%), and dilation of cardiac cavities and/or increased cardiac muscle thickness ( n = 8, 8.2%)]. Thirteen patients (13.5%) required intensive care. All patients received GCs [only GCs (group I; n = 65, 67%)], and 32 patients (33%) with severe manifestations and/or cardiac involvement received GCs + IVIG (group II). No mortality was observed. None of the patients had any complaints at the oneyear follow-up, and all echocardiography findings were normal. Conclusion: This study provides preliminary evidence that GC monotherapy is a safe treatment alternative for mild MIS-C cases without cardiac involvement. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
dc.identifier.citationSütçü, M., Kara, E. M., Yıldız, F., Gül, D., Yıldız, R., Yılmaz, D., ... & Özkaya, O. (2024). MIS-C Treatment: Is glucocorticoid monotherapy enough for mild cases?. The American Journal of Emergency Medicine, 83, 95-100.
dc.identifier.doi10.1016/j.ajem.2024.06.030
dc.identifier.endpage100
dc.identifier.issn0735-6757
dc.identifier.issn1532-8171
dc.identifier.pmid39002497
dc.identifier.scopus2-s2.0-85198170949
dc.identifier.scopusqualityQ1
dc.identifier.startpage95
dc.identifier.urihttp://dx.doi.org/10.1016/j.ajem.2024.06.030
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6980
dc.identifier.volume83
dc.identifier.wosWOS:001271372800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSütçü, Murat
dc.institutionauthorGül, Doruk
dc.institutionauthorYıldız, Funda
dc.institutionauthorAtik, Fatih
dc.institutionauthorÖzkaya, Ozan
dc.institutionauthoridMurat Sütçü / 0000-0002-2078-9796
dc.institutionauthoridGül Doruk / 0000-0003-2558-3719
dc.institutionauthoridFatih Atik / 0000-0003-4435-556X
dc.institutionauthoridOzan Özkaya / 0000-0002-0198-1221
dc.language.isoen
dc.publisherW B saunders co-elsevier
dc.relation.ispartofAmerican journal of emergency medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMultisysteminflammatory Syndrome in Chil-dren (MIS-C)
dc.subjectGlucocorticoid Monotherapy
dc.subjectCardiac Involvement
dc.titleMIS-C Treatment: Is glucocorticoid monotherapy enough for mild cases?
dc.typeArticle

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