Serum neutrophil gelatinase-associated lipocalin concentrations are significantly associated with the severity of COVID-19 in pregnant patients

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dc.authoridHuri Bulut / 0000-0003-2706-9625en_US
dc.authorscopusidHuri Bulut / 57185264300
dc.authorwosidHuri Bulut / AAM-1432-2020en_US
dc.contributor.authorCan, Esra
dc.contributor.authorÖlmez, Fatma
dc.contributor.authorBulut, Huri
dc.contributor.authorOğlak, Süleyman Cemil
dc.date.accessioned2022-06-16T06:02:02Z
dc.date.available2022-06-16T06:02:02Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: To evaluate serum neutrophil gelatinaseassociated lipocalin (NGAL) concentrations of pregnant women complicated with coronavirus disease 2019 (COVID-19) and investigate its diagnostic value for the severity of COVID-19. Methods: Of the 46 pregnant women with COVID-19 included in the study, we further classified these women into 2 subgroups: the non-severe COVID-19 group (n=25) and the severe COVID-19 group (n=21). Results: Neutrophil gelatinase-associated lipocalin plasma concentrations were significantly higher in pregnant women complicated with severe COVID-19 (90 [53.1-207.7] ng/ml) compared to those from Original Article pregnant women with non-severe COVID-19 (51.8 [39.6-70.3] ng/ml) and healthy pregnant women (44.3 [32.2-54.1] ng/ml, p<0.001). Also, at a cutoff value of 72 ng/ml, NGAL predicted severe COVID-19 with a sensitivity rate of 57% and a specificity rate of 84%. Serum NGAL level (adjusted hazard ratio [aHR]=1.020, 95% confidence interval [CI]= [1.006-1.035], p=0.007), and D-dimer level (aHR=2.371, 95% CI= [1.085-5.181], p=0.030) were the variables that were revealed to be significantly associated with the disease severity. Conclusion: We demonstrated that NGAL was highly associated with COVID-19 severity. We consider that NGAL might be a useful biomarker to diagnose the disease severity in patients with COVID-19.en_US
dc.identifier.citationCan E, Cemil Oğlak S, Ölmez F, Bulut H. Serum neutrophil gelatinase-associated lipocalin concentrations are significantly associated with the severity of COVID-19 in pregnant patients. Saudi Med J. 2022 Jun;43(6):559-566. doi: 10.15537/smj.2022.43.6.20220156. PMID: 35675933.en_US
dc.identifier.doi10.15537/smj.2022.43.6.20220156en_US
dc.identifier.endpage566en_US
dc.identifier.issn0379-5284en_US
dc.identifier.issue6en_US
dc.identifier.pmid35675933en_US
dc.identifier.scopus2-s2.0-85131648254en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage559en_US
dc.identifier.urihttp://doi.org/10.15537/smj.2022.43.6.20220156
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2906
dc.identifier.volume43en_US
dc.identifier.wosWOS:000811330900003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBulut, Huri
dc.language.isoenen_US
dc.publisherSaudimedjen_US
dc.relation.ispartofSaudi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectDisease Severityen_US
dc.subjectNeutrophil Gelatinase-Associated Lipocalinen_US
dc.titleSerum neutrophil gelatinase-associated lipocalin concentrations are significantly associated with the severity of COVID-19 in pregnant patientsen_US
dc.typeArticleen_US

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