The potential chemo-preventive roles of Malus domestica against the risk of colorectal cancer: A suggestive insight into clinical application

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dc.authoridAnmar Al-Taie / 0000-0002-2183-6830
dc.authorscopusidAnmar Al-Taie / 57221579036en_US
dc.authorwosidAnmar Al-Taie / ITV-8235-2023
dc.contributor.authorKöseoğlu, Aygül
dc.contributor.authorAl-Taie, Anmar
dc.date.accessioned2022-10-31T11:27:56Z
dc.date.available2022-10-31T11:27:56Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractBiologically active compounds in fruit-derived ingredients, particularly phytochemicals, have significant potential to modulate and mitigate many pathological processes in the development of disease conditions, including cancer. Colorectal cancer (CRC) remains a major public health issue. Nonetheless, prevention is an important step in lowering the rate of mortality from this cancer. Currently, the link between apple consumption and improved health is becoming remarkably evident and is reported to be beneficial for human health. Phytochemicals, such as flavonoids and other polyphenol compounds extensively available in apple fruits, have well-known positive effects on health outcomes and the potential to combat and prevent the development of CRC, including antioxidant, anti-proliferative, and anti-carcinogenic effects. This review describes the bioactive compounds derived from apple fruits, particularly the polyphenols and flavonoids, their proposed mechanisms responsible for their bioactive properties and health-promoting attributes that could provide potential chemo-preventive effects against the risk of CRC development. The conclusion of the review provides insights into the potential effects of apple-derived bioactive compounds and proposes the need for more clinical studies in large trials for future strategies regarding the valuable effects of apple phytochemicals, which might be therapeutic candidates in the campaign against CRC.en_US
dc.identifier.citationKoseoğlu, A., & Al-Taie, A. (2022). The potential chemo-preventive roles of malus domestica against the risk of colorectal cancer: A suggestive insight into clinical application. Clinical Nutrition ESPEN, doi:10.1016/j.clnesp.2022.09.017en_US
dc.identifier.doi10.1016/j.clnesp.2022.09.017en_US
dc.identifier.scopus2-s2.0-85139365716en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.clnesp.2022.09.017
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3216
dc.identifier.wosWOS:000907176300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAl-Taie, Anmar
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofClinical Nutrition ESPENen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAppleen_US
dc.subjectChemo-preventionen_US
dc.subjectColorectal Canceren_US
dc.subjectFlavonoidsen_US
dc.subjectMalus Domesticaen_US
dc.subjectPolyphenolsen_US
dc.titleThe potential chemo-preventive roles of Malus domestica against the risk of colorectal cancer: A suggestive insight into clinical applicationen_US
dc.typeReview Articleen_US

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