Evaluation of left ventricular function and myocardial deformation in children with beta-thalassemia major by real-time three-dimensional (four-dimensional) and speckle tracking echocardiography

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dc.authoridTülin Tiraje Celkan / 0000-0001-7287-1276
dc.authoridGül Nihal Özdemir / 0000-0002-3204-4353
dc.authorscopusidTülin Tiraje Celkan / 35584411200en_US
dc.authorscopusidGül Nihal Özdemir / 57208780173
dc.authorwosidGül Nihal Özdemir / AAO-9962-2020
dc.authorwosidTülin Tiraje Celkan / FZB-3980-2022
dc.contributor.authorEroğlu, Ayşe Güler
dc.contributor.authorUluğ, Nujin
dc.contributor.authorKarakaş, Hasan
dc.contributor.authorYüksel Karabıyık, Esra
dc.contributor.authorAkyel, Nazlı Gülsüm
dc.contributor.authorGülnaz, C. I.G.
dc.contributor.authorAdaletli, İbrahim
dc.contributor.authorÖzdemir, Gül Nihal
dc.contributor.authorTürkkan, Emine
dc.contributor.authorCelkan, Tülin Tiraje
dc.date.accessioned2022-11-08T13:58:02Z
dc.date.available2022-11-08T13:58:02Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: This study aimed to evaluate the role of real-time three-dimensional (four-dimensional) and speckle tracking echocardiography for early detection of left ventricular systolic dysfunction and also for the relationship between myocardial deformation parameters and myocardial iron load which is measured by cardiac magnetic resonance relaxation time T2* values in asymptomatic children with beta-thalassemia major. Material and Methods: This multicenter cross-sectional study included 40 patients (mean age 15.4 ± 2.9, 42.1% male) and 40 healthy children whose age, gender, and body mass index-matched with patients. Each participant underwent conventional echocardiography and tissue Doppler imaging. Left ventricular ejection fraction; global longitudinal, circumferential, radial strains; twist; and torsion were measured by real-time three-dimensional and speckle tracking echocardiography. Cardiac magnetic resonance imaging T2* was measured in patients. Results: Left ventricular global longitudinal, circumferential, and radial strains were decreased despite preserved global ventricular function in patients compared to healthy children (p = p =.029, p = p <.001, p =.003, respectively). There were no statistically significant differences between patients with T2* ? 20 ms and patients with T2* < 20 ms for all echocardiographic parameters. Also, there were no significant correlations between all echocardiographic parameters and T2* values in all patients, those with T2* ? 20 ms, and T2* < 20 ms. Conclusion: We found that even in asymptomatic children with beta-thalassemia major, left ventricular longitudinal, circumferential and, radial functions were impaired by real-time three-dimensional (four-dimensional) and speckle tracking echocardiography. This novel echocardiographic method might be an important tool for detecting subclinical left ventricular systolic dysfunction irrespective of T2* values.en_US
dc.identifier.citationEroğlu, A. G., Uluğ, N., Karakaş, H., Yüksel, E. K., Akyel, N. G., Gülnaz, Ç. ı. ğ., . . . Celkan, T. T. (2022). Evaluation of left ventricular function and myocardial deformation in children with beta-thalassemia major by real-time three-dimensional (four-dimensional) and speckle tracking echocardiography. Echocardiography, doi:10.1111/echo.15453en_US
dc.identifier.doi10.1111/echo.15453en_US
dc.identifier.scopus2-s2.0-85138266148en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1111/echo.15453
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3299
dc.identifier.wosWOS:000855482500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzdemir, Gül Nihal
dc.institutionauthorCelkan, Tülin Tiraje
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofEchocardiographyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBeta-thalassemia Majoren_US
dc.subjectFour-dimensional Echocardiographyen_US
dc.subjectMyocardial Deformationen_US
dc.subjectReal-time Three-dimensional Echocardiographyen_US
dc.subjectSpeckle Tracking Echocardiographyen_US
dc.titleEvaluation of left ventricular function and myocardial deformation in children with beta-thalassemia major by real-time three-dimensional (four-dimensional) and speckle tracking echocardiographyen_US
dc.typeArticleen_US

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