Investigation of diagnostic proteins by 2D electrophoresis in major de-pression model induced by forced swim test in rats

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dc.authoridHuri Bulut / 0000-0003-2706-9625en_US
dc.authorscopusidHuri Bulut / 57185264300
dc.authorwosidHuri Bulut / AAM-1432-2020
dc.contributor.authorDuman, Tuğçe
dc.contributor.authorAkyüz, Enes
dc.contributor.authorBulut, Huri
dc.contributor.authorKoçyiğit, Abdurrahim
dc.contributor.authorTülek, Ahmet
dc.contributor.authorKarataş, Ersin
dc.contributor.authorKırpınar, İsmet
dc.date.accessioned2020-09-24T13:57:36Z
dc.date.available2020-09-24T13:57:36Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Aside from its pervasiveness, whereby it affects as much as 20% of the world's population, depression continues to be one of the most crucial psychiatric problems due to the loss of power it causes by disrupting daily life functioning, containing economic consequences, and having a high suicidal tendency. Major depression (MD) is a systemic and multifactorial disorder involving complex interactions between genetic predisposition and disturbances of various molecular pathways. Objectives: In our current study, we aimed to identify the proteins obtained from serum samples that change during depression with the MD model. Methods: The MD model was applied through the forced swim test in rats. 14 Winstar Albino male rats were divided into two equal groupsas follows: depression and control groups. Serum samples were separated by chromatographic methods and then compared with two-dimensional (2D) electrophoresis. Results: A total of 9 potential diagnostic protein sequences were identified, which were distinguished with computer soft-ware. During the last phase of the study,the Matrix-Assisted Laser Desorption/Ionization -Time of Flight (MALDI-TOF) analysis, the previous expression sequences identified among the groups were determined and classified. By comparing protein expressions, it was concluded that 9 different points could be used together as a potential biomarker. Conclusion: Results can help us identify a new diagnostic system that can be used to diagnose MD.en_US
dc.identifier.citationDuman, T., Akyüz, E., Bulut, H., Koçyiğit, A., Tülek, A., KarataŞ, E., & Kırpınar, İ. (2020). Investigation of Diagnostic Proteins by 2D Electrophoresis in Major De-pression Model Induced by Forced Swim Test in Rats. Protein and Peptide Letters.en_US
dc.identifier.doi10.2174/0929866527999200729183729en_US
dc.identifier.pmid32729412en_US
dc.identifier.scopus2-s2.0-85103683442en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.2174/0929866527999200729183729
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1099
dc.identifier.wosWOS:000637726400008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBulut, Huri
dc.language.isoenen_US
dc.relation.ispartofProtein Pept Letten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2D Electrophoresisen_US
dc.subjectDepression Modelen_US
dc.subjectForcing Swimtesten_US
dc.subjectMajor Depressionen_US
dc.subjectProteinen_US
dc.subjectRatsen_US
dc.titleInvestigation of diagnostic proteins by 2D electrophoresis in major de-pression model induced by forced swim test in ratsen_US
dc.typeArticleen_US

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