A new inflammatory marker: elevated eosinophil-tolymphocyte ratio associated with presence and severity of isolated coronary artery ectasia

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dc.authoridHidayet Kayançiçek / 0000-0001-6493-5591
dc.authorscopusidHidayet Kayançiçek / 15837302900
dc.authorwosidHidayet Kayançiçek / DUY-5949-2022
dc.contributor.authorYılmaz, Mücahid
dc.contributor.authorKayançiçek, Hidayet
dc.contributor.authorKorkmaz, Hasan
dc.contributor.authorGözel, Nevzat
dc.contributor.authorBilen, Mehmet Nail
dc.contributor.authorSeçen, Özlem
dc.contributor.authorÖner, Pınar
dc.contributor.authorUku, Ökkeş
dc.contributor.authorDemirkıran, Suat
dc.contributor.authorÇekici, Yusuf
dc.contributor.authorEroğlu, Orkun
dc.date.accessioned2020-10-06T08:41:20Z
dc.date.available2020-10-06T08:41:20Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractObjectives: The pathophysiology of isolated coronary artery ectasia (CAE) involves atherosclerosis and inflammation. Eosinophils and lymphocytes have been found to play a significant role in inflammation, atherosclerosis and endothelial dysfunction. Many studies have explored the relationship between isolated CAE and systemic inflammation. However, there are no data regarding the relationship between eosinophil-to-lymphocyte ratio (ELR) and isolated CAE. Therefore, this study analysed the relationship between ELR and isolated CAE. Methods: All patients who underwent coronary angiography between January 2009 and June 2018 were investigated retrospectively. Of 16 240 patients, 232 patients with isolated CAE (141 males) and 247 age- and gender-matched control subjects (130 males) with normal coronary angiography (NCA) were enrolled in this study. Baseline demographic and laboratory data were obtained from the hospital database. The severity of isolated CAE was determined according to the Markis classification, vessel count and diffuseness of ectasia. Results: Patients with angiographic isolated CAE had significantly elevated white blood cell (WBC) and eosinophil counts and ELR values compared to patients with NCA [8.11 ± 1.75 vs 7.49 ± 1.80 × 109 cells/l, p < 0.0001; 0.22 (0.13-0.32) vs 0.19 (0.12-0.28) × 109 cells/l, p = 0.02; 0.11 (0.06-0.17) vs 0.08 (0.05-0.12), p < 0.0001. The ELR value for Markis I was significantly higher than for Markis IV (p = 0.04), and three-vessel isolated CAE was significantly higher than onevessel isolated CAE (p = 0.04). Additionally, the ELR value for diffuse ectasia (Markis class I, II and III) was significantly higher compared to focal (Markis class IV) ectasia (p = 0.02). In receiver operating characteristics (ROC) analyses, it was determined that an ELR value > 0.099, measured in isolated CAE patients at application, had a predictive specificity of 60.3% and a sensitivity of 56.5% (area under the curve: 0.604, 95% confidence interval: 0.553-0.655, p < 0.0001). Conclusions: Patients with isolated CAE had higher blood eosinophil counts and ELR. Furthermore, the ELR was significantly correlated with severity of isolated CAE. These findings demonstrate that ELR may have a significant role in the aetiopathogenesis of isolated CAE.en_US
dc.identifier.citationYilmaz, M., Kayançiçek, H., Korkmaz, H., Gözel, N., Bilen, M. N., Seçen, Ö., Öner, P., Uku, Ö., Demirkiran, S., Çekici, Y., Eroğlu, O., & Ertuğrul, K. (2020). A new inflammatory marker: elevated eosinophil-tolymphocyte ratio associated with presence and severity of isolated coronary artery ectasia. Cardiovascular journal of Africa, 31, 1–9. Advance online publication. https://doi.org/10.5830/CVJA-2019-049en_US
dc.identifier.doi10.5830/CVJA-2019-049en_US
dc.identifier.endpage9en_US
dc.identifier.issue31en_US
dc.identifier.scopus2-s2.0-85095861291en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.5830/CVJA-2019-049
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1131
dc.identifier.wosWOS:000587657400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKayançiçek, Hidayet
dc.language.isoenen_US
dc.relation.ispartofCardiovascular journal of Africaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEosinophil Counten_US
dc.subjectEosinophil‐to‐Lymphocyte Ratioen_US
dc.subjectIsolated Coronary Artery Ectasiaen_US
dc.subjectInflammationen_US
dc.titleA new inflammatory marker: elevated eosinophil-tolymphocyte ratio associated with presence and severity of isolated coronary artery ectasiaen_US
dc.typeArticleen_US

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