O/W microemulsion and hydrogel formulation of methotrexate and comparison of releasing studies.

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dc.authoridALPARSLAN, LEVENT/0000-0003-0113-6850
dc.contributor.authorAlparslan, Abdullah Levent
dc.contributor.authorKarasulu, Ercument
dc.contributor.authorTurkyilmaz, Gulbeyaz Yildiz
dc.contributor.authorUvey, Dogan
dc.date.accessioned2024-05-19T14:45:49Z
dc.date.available2024-05-19T14:45:49Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractMicroemulsions are ideal carriers for poorly soluble substances. They increase the absorption of drugs with low bioavailability. Methotrexate (MTX), which is used internally in cancer and psoriasis and has many side effects and it is less soluble in water and its passage through the skin is problematic due to its high molecular weight. An O/W microemulsion formulation containing MTX has been developed in order to reduce the side effects of the drug, not to have a first pass effect on the liver, to increase its bioavailability in topical use and to provide ease of use to patients. The releasing profiles of the gel formulation, prepared by reducing the fluidity of these formulations by polymers, were investigated through the nylon membrane. Mostly W/O microemulsion systems are available due to design of preparations but in this study O/W microemulsions and gel forms containing MTX were designed for topical use. Innovation side of trials will inspire in vivo studies and clinical studies that may cause less harm to patients dermatologically and provide optimal effect.en_US
dc.identifier.doi10.29228/jrp.367
dc.identifier.endpage882en_US
dc.identifier.issn2630-6344
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85151350803en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage873en_US
dc.identifier.trdizinid1177733en_US
dc.identifier.urihttps://doi.org10.29228/jrp.367
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1177733
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5355
dc.identifier.volume27en_US
dc.identifier.wosWOS:000990531300012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal of Research In Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectMicroemulsionen_US
dc.subjectOen_US
dc.subjectWen_US
dc.subjectHydrogelen_US
dc.subjectMetotrexateen_US
dc.subjectFranzcellen_US
dc.subjectTopicalen_US
dc.subjectReleaseen_US
dc.titleO/W microemulsion and hydrogel formulation of methotrexate and comparison of releasing studies.en_US
dc.typeArticleen_US

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