Comparison of oxidant/antioxidant balance in COPD and non-COPD smokers

Basit Öğe Kaydı
dc.authoridAdil Can Güngen / 0000-0002-2676-723Xen_US
dc.authorscopusidAdil Can Güngen / 56682130600
dc.authorwosidAdil Can Güngen / AAO-2470-2020
dc.contributor.authorAydemir, Yusuf
dc.contributor.authorAydemir, Özlem
dc.contributor.authorŞengül, Aysun
dc.contributor.authorGüngen, Adil Can
dc.contributor.authorÇoban, Hikmet
dc.contributor.authorTaşdemir, Canatan
dc.contributor.authorDüzenli, Hasan
dc.contributor.authorŞehitoğulları, Abidin
dc.date.accessioned2020-08-30T20:06:28Zen_US
dc.date.available2020-08-30T20:06:28Zen_US
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground/aim: Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Smoking is the leading source of oxidants in lungs. However, it is currently unknown why some individuals are more resistant to the detrimental effects of smoking and do not develop COPD. The aim in this study is to measure and compare the oxidant/antioxidant balance between in non-COPD individuals who smoke and COPD patients who smoke. Materials and methods: Included in the study were 137 patients with COPD and 102 healthy individuals. Participants were divided into groups as COPD patients (former and current smokers), non-COPD individuals who smoke and non-smokers healthy persons. In the following stage, the total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) levels were measured in serum for all participants. Results: In the current-smoker COPD group, the level of oxidant status were significantly higher than the former-smoker COPD group (p < 0.001). Similarly, oxidant levels were significantly high in current-smoker healthy group than never smoker healthy group. According to these results TOS was associated with especially smoking status rather than COPD. Antioxidant status were similar between former-smoker COPD group and current-smoker COPD group. The antioxidant levels were found significantly low in current-smoker COPD patients, compared to the current-smoker non-COPD individuals (p = 0.007). Nevertheless, no significant difference was found in OSI levels between two groups. Briefly, high TOS and OSI values were correlated with only smoking, independently from COPD. Conclusion: It was concluded that there are complex pathogenetic mechanisms, including genetic and individual variations other than oxidant/antioxidant balance, involved in the development of smoking-related COPD. TOS and OSI values are not predictive parameters for the development of COPD, but high level of TAS in non-COPD smokers is promising for future studies. (C) 2019 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipSakarya University Scientific Research FoundationSakarya University [2014/0806014]en_US
dc.description.sponsorshipThis work was supported by Sakarya University Scientific Research Foundation (Project number: 2014/0806014).en_US
dc.identifier.citationAydemir, Y., Aydemir, Ö., Şengül, A., Güngen, A. C., Çoban, H., Taşdemir, C., ... & Şehitoğulları, A. (2019). Comparison of oxidant/antioxidant balance in COPD and non-COPD smokers. Heart & Lung, 48(6), 566-569.en_US
dc.identifier.doi10.1016/j.hrtlng.2019.07.005en_US
dc.identifier.endpage569en_US
dc.identifier.issn0147-9563en_US
dc.identifier.issn1527-3288en_US
dc.identifier.issue6en_US
dc.identifier.pmid31371032en_US
dc.identifier.scopus2-s2.0-85069828162en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage566en_US
dc.identifier.urihttps://doi.org/10.1016/j.hrtlng.2019.07.005en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/524en_US
dc.identifier.volume49en_US
dc.identifier.wosWOS:000498324600014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGüngen, Adil Canen_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofHeart & Lungen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOPDen_US
dc.subjectOxidative Stressen_US
dc.subjectAntioxidanten_US
dc.subjectOxidanten_US
dc.titleComparison of oxidant/antioxidant balance in COPD and non-COPD smokersen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
71.pdf
Boyut:
334.87 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu