Synthesis, DNA binding and cytotoxic activity of newcopper(II) complexes of trisubstituted imidazoles
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study was aimed to synthesize and characterize two new copper(II) complexes, [Cu(phen)(Br-impi)]2+ (1) and [Cu(phen)(M-impi)]2+ (2) (where phen is 1,10-phenanthroline; Br-impi is 2-(2-(4-bromophenyl)-4- (pyridin-2-yl)-4,5-dihydro-1H-imidazol-5-yl)pyridine, andM-impi is 2-(2-(4-methoxyphenyl)-4-(pyridin- 2-yl)-4,5-dihydro-1H-imidazol-5-yl)pyridine), and to study their DNAbinding activity and cytotoxic activity. The interaction of complexes with ds-DNA has been investigated by spectroscopic methods, viscosity measurements, and agarose gel electrophoresis. The results indicate that complex 1 can bind to ds-DNA better than doescomplex 2 with binding constants 1.9 × 105M-1 and 3.9 × 104M-1, respectively.According to the UV titration method, complex 1 is capable of extractingethidium bromide molecules from DNA base pairs at lower concentrations than complex 2. In oxidative medium, both complexes produce complete degradationof plasmid DNA. Thecomplexes were screened against five human cell lines, namely A 549, PC-3, BEAS-2B, HCT-116 and MDZ-MB-231, and it was found that copper(II) complexes of trisubstituted imidazoleexhibited cytotoxic activity. © 2022, Springer Science+Business Media, LLC, part of Springer Nature.
Açıklama
Anahtar Kelimeler
Copper(II) Complex, DNA Binding, Imidazole, Cytotoxic Effect, Local Chemotherapy
Kaynak
Pharmaceutical Chemistry Journal
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
Sayı
Künye
Gerçek, Z., Yıldız, U., Ulukaya, E., & Akar, R. O. (2022). Synthesis, DNA binding and cytotoxic activity of newcopper(II) complexes of trisubstituted imidazoles. Pharmaceutical Chemistry Journal, doi:10.1007/s11094-022-02578-2
