Synthesis, DNA binding and cytotoxic activity of newcopper(II) complexes of trisubstituted imidazoles

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authoridRemzi Okan Akar / 0000-0001-8687-2034en_US
dc.authorscopusidRemzi Okan Akar / 57210603359en_US
dc.authorscopusidEngin Ulukaya / 6602927353en_US
dc.authorwosidRemzi Okan Akar / AAF-4576-2019en_US
dc.authorwosidEngin Ulukaya / K-5792-2018en_US
dc.contributor.authorGerçek, Zuhal
dc.contributor.authorYıldız, Ufuk
dc.contributor.authorUlukaya, Engin
dc.contributor.authorAkar, Remzi Okan
dc.date.accessioned2022-03-15T05:52:43Z
dc.date.available2022-03-15T05:52:43Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThis study was aimed to synthesize and characterize two new copper(II) complexes, [Cu(phen)(Br-impi)]2+ (1) and [Cu(phen)(M-impi)]2+ (2) (where phen is 1,10-phenanthroline; Br-impi is 2-(2-(4-bromophenyl)-4- (pyridin-2-yl)-4,5-dihydro-1H-imidazol-5-yl)pyridine, andM-impi is 2-(2-(4-methoxyphenyl)-4-(pyridin- 2-yl)-4,5-dihydro-1H-imidazol-5-yl)pyridine), and to study their DNAbinding activity and cytotoxic activity. The interaction of complexes with ds-DNA has been investigated by spectroscopic methods, viscosity measurements, and agarose gel electrophoresis. The results indicate that complex 1 can bind to ds-DNA better than doescomplex 2 with binding constants 1.9 × 105M-1 and 3.9 × 104M-1, respectively.According to the UV titration method, complex 1 is capable of extractingethidium bromide molecules from DNA base pairs at lower concentrations than complex 2. In oxidative medium, both complexes produce complete degradationof plasmid DNA. Thecomplexes were screened against five human cell lines, namely A 549, PC-3, BEAS-2B, HCT-116 and MDZ-MB-231, and it was found that copper(II) complexes of trisubstituted imidazoleexhibited cytotoxic activity. © 2022, Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.identifier.citationGerçek, Z., Yıldız, U., Ulukaya, E., & Akar, R. O. (2022). Synthesis, DNA binding and cytotoxic activity of newcopper(II) complexes of trisubstituted imidazoles. Pharmaceutical Chemistry Journal, doi:10.1007/s11094-022-02578-2en_US
dc.identifier.doi10.1007/s11094-022-02578-2en_US
dc.identifier.issn0091-150Xen_US
dc.identifier.scopus2-s2.0-85125658616en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.1007/s11094-022-02578-2
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2549
dc.identifier.wosWOS:000765036000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorUlukaya, Engin
dc.institutionauthorAkar, Remzi Okan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCopper(II) Complexen_US
dc.subjectDNA Bindingen_US
dc.subjectImidazoleen_US
dc.subjectCytotoxic Effecten_US
dc.subjectLocal Chemotherapyen_US
dc.titleSynthesis, DNA binding and cytotoxic activity of newcopper(II) complexes of trisubstituted imidazolesen_US
dc.typeArticleen_US

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