The prognostic and predictive values of differential expression of exosomal receptor tyrosine kinases and associated with the PI3K/AKT/mTOR signaling in breast cancer patients undergoing neoadjuvant chemotherapy

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dc.authoridCemil Bilir / 0000-0002-1372-4791
dc.authorscopusidCemil Bilir / 23666163400en_US
dc.authorwosidCemil Bilir / DTZ-3231-2022en_US
dc.contributor.authorGüney Eskiler, Gamze
dc.contributor.authorKazan, Nur
dc.contributor.authorHacıefendi, Ayten
dc.contributor.authorDeveci Özkan, Asuman
dc.contributor.authorÖzdemir, Kayhan
dc.contributor.authorÖzen, Miraç
dc.contributor.authorKoçer, Havva Belma
dc.contributor.authorYılmaz, Fahri
dc.contributor.authorKaleli, Süleyman
dc.contributor.authorŞahin, Elvan
dc.contributor.authorBilir, Cemil
dc.date.accessioned2022-11-04T05:15:56Z
dc.date.available2022-11-04T05:15:56Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: Cancer cell-derived exosomes are the mediator of the tumor microenvironment and the molecular content of exosomes presents a promising prognostic or predictive marker in tumor progression and the treatment response of cancer patients. The aim of this study was to identify the expression levels of receptor tyrosine kinases (RTKs) and AKT1 and mTOR before and after neoadjuvant chemotherapy (NACT) in the exosomes of BC patients compared with healthy females. Methods: After isolating exosomes in the serum of 25 BC patients and characterization by flow cytometry, the mRNA levels of FGFR2, FGFR3, PDGFRB, AKT1 and mTOR in the exosomes were analyzed by RT-PCR. Results: Our preliminary findings showed that FGFR2, PDGFRB, AKT1 and mTOR levels were significantly upregulated in BC patients before NACT compared with the healthy group (p < 0.05). Furthermore, the mRNA levels PDGFRB and AKT1 were significantly down-regulated after NACT compared with control. PDGFRB expression level could predict pathological non-response and significantly correlated with tumor size after NACT. Conclusion: Therefore, especially FGFR2, PDGFRB and AKT1 could be a therapeutic target as a prognostic marker, whereas PDGFRB may be a promising predictive indicator of therapy response in BC patients. However, the prognostic or predictive role of RTKs and PI3K/AKT/mTOR signaling in the exosomes should be further investigated in a large patient population.en_US
dc.identifier.citationGuney Eskiler, G., Kazan, N., Haciefendi, A., Deveci Ozkan, A., Ozdemir, K., Ozen, M., . . . Bilir, C. (2022). The prognostic and predictive values of differential expression of exosomal receptor tyrosine kinases and associated with the PI3K/AKT/mTOR signaling in breast cancer patients undergoing neoadjuvant chemotherapy. Clinical and Translational Oncology, doi:10.1007/s12094-022-02959-9en_US
dc.identifier.doi10.1007/s12094-022-02959-9en_US
dc.identifier.scopus2-s2.0-85139248945en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1007/s12094-022-02959-9
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3218
dc.identifier.wosWOS:000862536300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBilir, Cemil
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofClinical and Translational Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectExosomesen_US
dc.subjectPI3K/AKT/mTOR Signalingen_US
dc.subjectReceptor Tyrosine Kinasesen_US
dc.titleThe prognostic and predictive values of differential expression of exosomal receptor tyrosine kinases and associated with the PI3K/AKT/mTOR signaling in breast cancer patients undergoing neoadjuvant chemotherapyen_US
dc.typeArticleen_US

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