Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients

dc.authoridBurak Önal / 0000-0002-7846-875X
dc.authorscopusidBurak Önal / 57203380129
dc.contributor.authorKandaz, Cemre
dc.contributor.authorÖnal, Burak
dc.contributor.authorÖzen, Deniz
dc.contributor.authorDemir, Bülent
dc.contributor.authorAkkan, A. Gökhan
dc.contributor.authorÖzyazgan, Sibel
dc.date.accessioned2020-08-30T20:07:43Z
dc.date.available2020-08-30T20:07:43Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackgroundDefinition of Cardiac Syndrome X (CSX) refers to groups of patients with positive exercise stress test and normal epicardial coronary arteries on coronary angiography accompanied by chest pain. Although the etiology of CSX is not completely understood, there is a common consensus that its pathophysiology may be associated with endothelial dysfunction resulting in impaired coronary flow. Some polymorphisms observed on the MTHFR gene cause inactivation of the MTHFR enzyme, leading to hyperhomocysteinemia and homocysteinuria, which are prominent risk factors of cardiovascular and cerebrovascular diseases. It was aimed to explain the association of the endothelial dysfunction, which is thought to play a role in the pathophysiology of CSX, with C677T polymorphism on MTHFR gene based on genetic basis. MethodsA total of 176 CSX patients and 196 healthy subjects with similar age and clinical features were compared in terms of C677T polymorphism of the MTHFR gene. Results and ConclusionThere was no significant difference in terms of MTHFR gene C677T polymorphism between CSX patients and controls. When genotypic distribution was compared based on gender in both patients and controls, no significant difference was found between male and female subjects (P>.05). As fasting blood sugar and urea values were significantly higher, alanine aminotransferase and gamma-glutamyl transferase levels were significantly lower in the patients than the controls (P<.05). Described family story of the patients was significantly higher than the controls (P<.05). These suggest that homocysteine metabolism in CSX is not directly related to the endothelial dysfunction and thus the effect on the microvascular circulation.en_US
dc.identifier.citationKandaz, C., Önal, B., Özen, D., Demir, B., Akkan, A. G., & Özyazgan, S. (2018). Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients. Journal of clinical laboratory analysis, 32(2), e22247.en_US
dc.identifier.doi10.1002/jcla.22247en_US
dc.identifier.issn0887-8013en_US
dc.identifier.issn1098-2825en_US
dc.identifier.issue2en_US
dc.identifier.pmid28481466en_US
dc.identifier.scopus2-s2.0-85018407164en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/jcla.22247
dc.identifier.urihttps://hdl.handle.net/20.500.12713/818
dc.identifier.volume32en_US
dc.identifier.wosWOS:000425109100023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖnal, Buraken_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Laboratory Analysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectC677ten_US
dc.subjectCardiac Syndrome Xen_US
dc.subjectMicrovascular Dysfunctionen_US
dc.subjectMthfren_US
dc.subjectPolymorphismen_US
dc.titleInvestigation of MTHFR gene C677T polymorphism in cardiac syndrome X patientsen_US
dc.typeArticleen_US

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