The importance of SNPs at miRNA binding sites as biomarkers of gastric and colorectal cancers: a systematic review

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorHajibabaie, Fatemeh
dc.contributor.authorAbedpoor, Navid
dc.contributor.authorAssareh, Nazanin
dc.contributor.authorTabatabaiefar, Mohammad Amin
dc.contributor.authorShariati, Laleh
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2022-04-06T05:39:41Z
dc.date.available2022-04-06T05:39:41Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractDysregulated mRNA-miRNA profiles might have the prospective to be used for early diagnosis of gastrointestinal cancers, estimating survival, and predicting response to treatment. Here, a novel biomarker based on miRNAs binding to mRNAs in single nucleotide polymorphism (SNP) sites related to gastrointestinal cancers is introduced that could act as an early diagnosis. The electronic databases used for the recruiting published articles included EMBASE, SCOPUS, Web of Science, and PubMed, based on MESH keywords and PRISMA methodology. Based on the considered criteria, different experimental articles were reviewed, during which 15 studies with the desired criteria were collected. Accordingly, novel biomarkers in prediction, early prognosis, and diagnosis of gastrointestinal cancers were highlighted. Moreover, it was found that 20 SNP sites and 16 miRNAs were involved in gastrointestinal cancers, with altered expression patterns associated with clinicopathological and demographic data. The results of this systematic study revealed that SNPs could affect the binding of miRNAs in the SNP sites that might play a principal role in the progression, invasion, and susceptibility of gastrointestinal cancers. In addition, it was found that the profiles of SNPs and miRNAs could serve as a convenient approach for the prognosis and diagnosis of gastric and colorectal cancers.en_US
dc.identifier.citationHajibabaie, F., Abedpoor, N., Assareh, N., Tabatabaiefar, M. A., Shariati, L., & Zarrabi, A. (2022). The Importance of SNPs at miRNA Binding Sites as Biomarkers of Gastric and Colorectal Cancers: A Systematic Review. Journal of personalized medicine, 12(3), 456.en_US
dc.identifier.doi10.3390/jpm12030456en_US
dc.identifier.issue3en_US
dc.identifier.pmid35330456en_US
dc.identifier.scopus2-s2.0-85127551115en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://10.3390/jpm12030456
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2605
dc.identifier.volume12en_US
dc.identifier.wosWOS:000774790600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.relation.ispartofPers Meden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiomarkersen_US
dc.subjectColorectal Canceren_US
dc.subjectGastric Canceren_US
dc.subjectmiRNAen_US
dc.subjectSingle Nucleotide Polymorphismen_US
dc.titleThe importance of SNPs at miRNA binding sites as biomarkers of gastric and colorectal cancers: a systematic reviewen_US
dc.typeReview Articleen_US

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