Comparison of platelet-rich plasma-impregnated suture material with low and high platelet concentration to improve colonic anastomotic wound healing in rats

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dc.authoridGülcan Sağlam / 0000-0002-7540-673Xen_US
dc.authorscopusidGülcan Sağlam / 56006708800
dc.authorwosidGülcan Sağlam / FXS-4905-2022
dc.contributor.authorAydin, Mehmet Akif
dc.contributor.authorGuler, Eray Metin
dc.contributor.authorDemiroz, Ahu Senem
dc.contributor.authorAydin, Muhammet Fatih
dc.contributor.authorSağlam, Gülcan
dc.date.accessioned2020-08-30T20:06:10Z
dc.date.available2020-08-30T20:06:10Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective. This study was designed to investigate the impact of using suture material impregnated with platelet-rich plasma (PRP) in different platelet concentrations on colonic anastomotic wound healing in rats. Methods. A total of 24 Sprague Dawley female rats were separated into 3 groups (n=8 for each) including the control group (CON; standard vicryl suture repair), the low platelet concentrate PRP group (L-PRP; suture material impregnated with PRP containing average 2.7-fold (range, 2.0 to 3.1) higher amount of platelets vs. control), and the high platelet concentrate PRP group (H-PRP; suture material impregnated with PRP containing average 5.1-fold (range, 4.8 to 5.4) higher amount of platelets vs. control). Rats were sacrificed on the postoperative 7(th) day for analysis of colonic anastomosis region including macroscopic observation, measurement of anastomotic bursting pressure (ABP), and the hydroxyproline levels and histopathological findings in colon tissue samples. Results. Total injury scores were significantly lower in the L-PRP and H-PRP groups than those in the control group (median (range) 13.00 (7.00) and 11.50 (6.00) vs. 15.50 (4.00), p<0.05 and p<0.01, respectively). ABP values (180.00 (49.00) vs. 124.00 (62.00) and 121.00 (57.00) mmHg, p<0.001 for each) and tissue hydroxyproline levels (0.56 (0.37) vs. 0.25 (0.17) and 0.39 (0.10) mu g/mg tissue, p<0.001 and p<0.05, respectively) were significantly higher in the L-PRP group as compared with those in the control and H-PRP groups. Conclusion. In conclusion, our findings revealed PRP application to colonic anastomosis sutures to promote the anastomotic healing process. The platelet concentration of PRP seems to have a significant impact on the outcome with superior efficacy of L-PRP over H-PRP in terms of bursting pressures and collagen concentration at the anastomotic site.en_US
dc.identifier.citationAydin, M. A., Guler, E. M., Demiroz, A. S., Aydin, M. F., & Saglam, G. (2020). Comparison of Platelet-Rich Plasma-Impregnated Suture Material with Low and High Platelet Concentration to Improve Colonic Anastomotic Wound Healing in Rats. Gastroenterology Research and Practice, 2020.en_US
dc.identifier.doi10.1155/2020/7386285en_US
dc.identifier.issn1687-6121en_US
dc.identifier.issn1687-630Xen_US
dc.identifier.pmid32565785en_US
dc.identifier.scopus2-s2.0-85087208118en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1155/2020/7386285
dc.identifier.urihttps://hdl.handle.net/20.500.12713/405
dc.identifier.volume2020en_US
dc.identifier.wosWOS:000540580600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSağlam, Gülcanen_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofGastroenterology Research and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleComparison of platelet-rich plasma-impregnated suture material with low and high platelet concentration to improve colonic anastomotic wound healing in ratsen_US
dc.typeArticleen_US

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