Carbon-based nanozymes for cancer therapy and diagnosis: a review

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dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorCordani, Marco
dc.contributor.authorFernández-Lucas, Jesús
dc.contributor.authorKhosravi, Arezoo
dc.contributor.authorZare, Ehsan Nazarzadeh
dc.contributor.authorMakvandi, Pooyan
dc.contributor.authorZarrabi, Ali
dc.contributor.authorIravani, Siavash
dc.date.accessioned2025-04-17T10:55:06Z
dc.date.available2025-04-17T10:55:06Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractCarbon-based nanozymes (CNs) have emerged as a significant innovation in targeted cancer therapy, demonstrating great potential for advancing cancer diagnosis and treatment. With exceptional catalytic properties, remarkable biocompatibility, and the ability to precisely target cancer cells, CNs provide a promising avenue for the development of novel oncological therapies. By functionalizing their surfaces with targeting ligands, such as antibodies or peptides, CNs can specifically recognize and bind to cancer cells. This targeted approach ensures that therapeutic agents are delivered directly to the tumor site, minimizing off-target effects, and reducing systemic toxicity. Additionally, the enzyme-like activities of CNs, when combined with conventional therapies such as chemotherapeutics, photothermal therapy, and photodynamic therapy, or other modalities can enhance therapeutic outcomes. Integrating CNs into clinical practice could significantly improve therapeutic efficacy, reduce probable side effects, enhance patient outcomes, and drive a shift towards more personalized cancer care. Besides, CNs can also be employed in biosensors and diagnostic nanomaterials, enabling rapid, selective, and highly accurate detection of specific biomarkers. Their versatile functionalities open new avenues for refining imaging techniques, ultimately contributing to early diagnosis and better clinical decision-making. This review consolidates recent studies exploring CNs in cancer targeting, highlighting both their diagnostic and therapeutic potential in oncology.
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades European Union Next GenerationEU Agencia Estatal de Investigación
dc.identifier.citationCordani, M., Fernández-Lucas, J., Khosravi, A., Zare, E. N., Makvandi, P., Zarrabi, A., & Iravani, S. (2025). Carbon-based nanozymes for cancer therapy and diagnosis: A review. International Journal of Biological Macromolecules, 139704.
dc.identifier.doi10.1016/j.ijbiomac.2025.139704
dc.identifier.endpage18
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid39793785
dc.identifier.scopus2-s2.0-85215442115
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1016/j.ijbiomac.2025.139704
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6208
dc.identifier.volume297
dc.identifier.wosWOS:001414369400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorZarrabi, Ali
dc.institutionauthoridAli Zarrabi / 0000-0003-0391-1769
dc.language.isoen
dc.publisherElsevier b.v.
dc.relation.ispartofInternational journal of biological macromolecules
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarbon-Based Nanozymes
dc.subjectPrecision Oncology
dc.subjectTargeted Cancer Therapy
dc.titleCarbon-based nanozymes for cancer therapy and diagnosis: a review
dc.typeOther

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