Long non-coding RNAs as new players in bladder cancer: Lessons from pre-clinical and clinical studies

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorMirzaei S.
dc.contributor.authorPaskeh M.D.A.
dc.contributor.authorHashemi F.
dc.contributor.authorZabolian A.
dc.contributor.authorHashemi M.
dc.contributor.authorEntezari M.
dc.contributor.authorTabari T.
dc.contributor.authorZarrabi A.
dc.date.accessioned2021-12-07T05:28:24Z
dc.date.available2021-12-07T05:28:24Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractThe clinical management of bladder cancer (BC) has become an increasing challenge due to high incidence rate of BC, malignant behavior of cancer cells and drug resistance. The non-coding RNAs are considered as key factors involved in BC progression. The long non-coding RNAs (lncRNAs) are RNA molecules and do not encode proteins. They have more than 200 nucleotides in length and affect gene expression at epigenetic, transcriptional and post-transcriptional phases. The lncRNAs demonstrate abnormal expression in BC cells and tissues. The present aims to identifying lncRNAs with tumor-suppressor and tumor-promoting roles, and evaluating their roles as regulatory of growth and migration. Apoptosis, glycolysis and EMT are tightly regulated by lncRNAs in BC. Response of BC cells to cisplatin, doxorubicin and gemcitabine chemotherapy is modulated by lncRNAs. LncRNAs regulate immune cell infiltration in tumor microenvironment and affect response of BC cells to immunotherapy. Besides, lncRNAs are able to regulate microRNAs, STAT3, Wnt, PTEN and PI3K/Akt pathways in affecting both proliferation and migration of BC cells. Noteworthy, anti-tumor compounds and genetic tools such as siRNA, shRNA and CRISPR/Cas systems can regulate lncRNA expression in BC. Finally, lncRNAs and exosomal lncRNAs can be considered as potential diagnostic and prognostic tools in BC.en_US
dc.identifier.citationMirzaei, S., Paskeh, M. D. A., Hashemi, F., Zabolian, A., Hashemi, M., Entezari, M., ... & Hushmandi, K. (2021). Long non-coding RNAs as new players in bladder cancer: Lessons from pre-clinical and clinical studies. Life Sciences, 119948.en_US
dc.identifier.doi10.1016/j.lfs.2021.119948en_US
dc.identifier.issn0024-3205en_US
dc.identifier.pmid34520771en_US
dc.identifier.scopus2-s2.0-85120174680en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2021.119948
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2309
dc.identifier.wosWOS:000778693800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryDiÄŸeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomarkeren_US
dc.subjectBladder Canceren_US
dc.subjectCancer Therapyen_US
dc.subjectImmune Evasionen_US
dc.subjectLncRNAen_US
dc.subjectTumor Microenvironmenten_US
dc.titleLong non-coding RNAs as new players in bladder cancer: Lessons from pre-clinical and clinical studiesen_US
dc.typeReview Articleen_US

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