Assessment of the Clinical Course of Human Rhinovirus/Enterovirus Infections in Pediatric Intensive Care

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dc.authoridAkçay, Nihal/0000-0002-8273-2226
dc.authoridTelhan, Leyla/0000-0003-0037-7636
dc.authoridKANGIN, MURAT/0000-0003-0042-0569
dc.authoridMenentoglu, Mehmet emin/0000-0003-3839-4722
dc.authoridTugrul, Hazal ceren/0000-0003-4990-0408
dc.authoridSEVKETOGLU, ESRA/0000-0002-8330-2877
dc.authoridDurak, Cansu/0000-0001-6309-8859
dc.authorwosidBarlas, Ulkem/JRZ-0705-2023
dc.authorwosidAkçay, Nihal/ACQ-1470-2022
dc.contributor.authorBarlas, Ulkem Kocoglu
dc.contributor.authorAkcay, Nihal
dc.contributor.authorMenentoglu, Mehmet Emin
dc.contributor.authorSevketoglu, Esra
dc.contributor.authorDuyu, Muhterem
dc.contributor.authorTelhan, Leyla
dc.contributor.authorKangin, Murat
dc.date.accessioned2024-05-19T14:41:18Z
dc.date.available2024-05-19T14:41:18Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: This study aims to evaluate the clinical course of human rhinovirus/enterovirus (HRV/EV) infections in the pediatric intensive care unit.Methods: The study was conducted as a multicenter, prospective observational study from September 2022 to December 2022. Cases with positive polymerase chain reaction testing for HRV/EV of nasopharyngeal swab samples within the first 24 hours of pediatric intensive care unit admission were recorded. There were 2 groups: 1-24 months and >24 months.Results: A total of 75 cases (39 male) were included in the study. The median age for all cases was 21 months. The highest polymerase chain reaction positivity rates were observed in October (37.33%). Among the cases, 32 (42.67%) presented with bronchopneumonia/pneumonia, 24 (32%) presented with acute bronchiolitis/bronchitis and 7 (9.33%) presented with sepsis/septic shock. The frequency of pediatric acute respiratory distress syndrome was found to be 6.67%. In the age group of 1-24 months, mean lymphocyte and liver enzyme levels were higher, while in the age group of >24 months, mean hemoglobin and mean kidney function test levels were higher (P <= 0.05). Continuous oxygen therapy was provided to 65.3% of the cases, noninvasive ventilation to 33.3%, high-flow nasal cannula-oxygen therapy to 32% and invasive mechanical ventilation to 16%.Conclusions: HRV/EV infections primarily affect the respiratory system and generally exhibit a clinical course with low mortality rates (1, 1.3%). In cases with underlying chronic diseases, more severe clinical conditions such as pediatric acute respiratory distress syndrome and septic shock may occur.en_US
dc.identifier.doi10.1097/INF.0000000000004127
dc.identifier.endpageE460en_US
dc.identifier.issn0891-3668
dc.identifier.issn1532-0987
dc.identifier.issue12en_US
dc.identifier.pmid37820286en_US
dc.identifier.scopus2-s2.0-85178495862en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE454en_US
dc.identifier.urihttps://doi.org10.1097/INF.0000000000004127
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5090
dc.identifier.volume42en_US
dc.identifier.wosWOS:001107102900028en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofPediatric Infectious Disease Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectEnterovirusen_US
dc.subjectIntensive Careen_US
dc.subjectPediatricen_US
dc.subjectRhinovirusen_US
dc.subjectVentilationen_US
dc.titleAssessment of the Clinical Course of Human Rhinovirus/Enterovirus Infections in Pediatric Intensive Careen_US
dc.typeArticleen_US

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