Trans-Pd/Pt(II) saccharinate complexes with a phosphine ligand: Synthesis, cytotoxicity and structure-activity relationship

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.contributor.authorİçsel, Ceyda
dc.contributor.authorYılmaz, Veysel T.
dc.contributor.authorAygün, Muhittin
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2020-08-30T20:06:12Z
dc.date.available2020-08-30T20:06:12Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionUlukaya, Engin (isu author)
dc.description.abstractNew trans-[Pd(sac)(2)(PPhMe2)(DMSO)]center dot H2O (Pd) and trans-[Pt(sac)(2)(PPhMe2)(2)]center dot H2O (Pt) complexes (sac = saccharinate and PPhMe 2 = dimethylphenylphosphine) were synthesized and characterized by elemental analysis, IR, NMR, ESI-MS spectral analyses and X-ray diffraction. The complexes were evaluated for their in vitro cytotoxicity against breast (MCF-7), colon (HCT116) and lung (A549) human cancer cell lines. The ATP viability assay displayed that Pd was biologically inactive, but Pt showed significant anticancer potency on MCF-7 cancer cells, similar to cisplatin. The results suggested that Pt targeted DNA, whereas Pd displayed higher binding affinity towards human serum albumin (HSA). Mechanism of action studies of Pt suggested apoptotic cell death due to significant increase in intracellular ROS (reactive oxygen species) levels, mitochondrial damage and formation of DNA double-strand breaks. Finally, this work represents a new example of potent transplatin anticancer complexes.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [215Z230]en_US
dc.description.sponsorshipWe thank the Scientific and Technological Research Council of Turkey (TUBITAK) for the financial support for the research project 215Z230.en_US
dc.identifier.citationIcsel, C., Yilmaz, V. T., Aygun, M., & Ulukaya, E. (2020). Trans-Pd/Pt(II) saccharinate complexes with a phosphine ligand: Synthesis, cytotoxicity and structure-activity relationship. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 30(9). https://doi.org/10.1016/j.bmcl.2020.127077en_US
dc.identifier.doi10.1016/j.bmcl.2020.127077en_US
dc.identifier.issn0960-894Xen_US
dc.identifier.issn1464-3405en_US
dc.identifier.issue9en_US
dc.identifier.pmid32156495en_US
dc.identifier.scopus2-s2.0-85081271622en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2020.127077
dc.identifier.urihttps://hdl.handle.net/20.500.12713/417
dc.identifier.volume30en_US
dc.identifier.wosWOS:000522861200027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofBioorganic & Medicinal Chemistry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTrans-Pd/Pt Complexesen_US
dc.subjectSaccharinateen_US
dc.subjectPhosphineen_US
dc.subjectDna Damageen_US
dc.subjectCytotoxicityen_US
dc.titleTrans-Pd/Pt(II) saccharinate complexes with a phosphine ligand: Synthesis, cytotoxicity and structure-activity relationshipen_US
dc.typeArticleen_US

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