Current status of mucoadhesive gel systems for buccal drug delivery

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dc.authoridEce Özcan Bülbül / 0000-0001-7112-923Xen_US
dc.authorscopusidEce Özcan Bülbül / 57211920637
dc.authorwosidEce Özcan Bülbül / ACE-7724-2022
dc.contributor.authorÜstündağ Okur, Neslihan
dc.contributor.authorÖzcan Bülbül, Ece
dc.contributor.authorYağcılar, Ayşe Pınar
dc.contributor.authorSiafaka, Panoraia I.
dc.date.accessioned2021-03-18T08:45:07Z
dc.date.available2021-03-18T08:45:07Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümüen_US
dc.description.abstractBackground: Buccal drug delivery is a fascinating research field. Gel-based formulations present potent characteristics as buccal systems since they have great physicochemical properties. Methods: Among the various gels, in situ gels that are viscous colloidal systems consisted of polymers when physiological conditions change (pH, temperature, ion activation) shift to the gel phase. These systems can improve bioavailability. Other systems such as nanogels or emulgels can be also applied for buccal delivery with promising results. Polymeric gel-based systems can be produced by natural, semisynthetic, and synthetic polymers. Their main advantage is that the active molecules can be released in a sustained and controllable manner. Several gels based on chitosan are produced for the entrapment of drugs demonstrating efficient retention time and bioavailability, due to chitosan mucoadhesion. Besides polysaccharides, poloxamers and Carbopol are also used in buccal gels due to their high swelling ability and reversed thermal gelation behavior. Results: Herein, the authors focused on the current development of mucoadhesive gel systems used in buccal drug delivery. After explaining buccal drug delivery and mucoadhesion, various studies with hydrogels, in situ gels, and nanogels were analyzed as buccal gel systems. Various mucoadhesive gel studies with mucoadhesive polymers have been studied and summarized. This review is presented as valuable guidance to scientists in formulating buccal mucoadhesive drug delivery systems. Conclusions: This review aimed to assist researchers working on buccal drug delivery by summarizing buccal drug delivery, mucoadhesion, and buccal mucoadhesive gel systems recently found in the literature.en_US
dc.identifier.citationOkur, N. Ü., Bülbül, E. Ö., Yağcılar, A. P., & Siafaka, P. I. (2021). Current Status of Mucoadhesive Gel Systems for Buccal Drug Delivery. Current pharmaceutical design, 10.2174/1381612824666210316101528. Advance online publication. https://doi.org/10.2174/1381612824666210316101528en_US
dc.identifier.doi10.2174/1381612824666210316101528en_US
dc.identifier.pmid33726644en_US
dc.identifier.scopus2-s2.0-85108076861en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.2174/1381612824666210316101528
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1604
dc.identifier.wosWOS:000657490000005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzcan Bülbül, Ece
dc.language.isoenen_US
dc.publisherBentham Scienceen_US
dc.relation.ispartofCurrent Pharmaceutical Designen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBuccal Drug Deliveryen_US
dc.subjectBuccal Routeen_US
dc.subjectHydrogelsen_US
dc.subjectIn Situ Gelsen_US
dc.subjectMucoadhesive Polymersen_US
dc.subjectNanogelsen_US
dc.titleCurrent status of mucoadhesive gel systems for buccal drug deliveryen_US
dc.typeArticleen_US

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