Differential of cholangiocarcinoma disease using Raman spectroscopy combined with multivariate analysis

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472
dc.authoridHuri Bulut / AAM-1432-2020
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidHuri Bulut / 57185264300
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.authorwosidHuri Bulut / AAM-1432-2020
dc.contributor.authorDepciuch, Joanna
dc.contributor.authorParlinska-Wojtan, Magdalena
dc.contributor.authorSerin, Kürşat Rahmi
dc.contributor.authorBulut, Huri
dc.contributor.authorUlukaya, Engin
dc.contributor.authorTarhan, Nevzat
dc.contributor.authorGüleken, Zozan
dc.date.accessioned2022-02-16T06:10:40Z
dc.date.available2022-02-16T06:10:40Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractCholangiocarcinoma (CCA) is a type of cancer, which 5-year survival is lower than 20 %, and which is detected mostly in advanced stage of the disease. Unfortunately, there are no diagnostic tools, which could show changes in the body indicating the development of the disease. Therefore, in this study, we investigate Raman spectroscopy as a promising analytical tool in medical diagnostics and as a method, which would allow to distinguish between healthy patients and patients suffering from cholangiocarcinoma. The obtained Raman spectra showed, that lower intensities of peaks corresponding to amino acids and proteins, as well as higher intensities of peaks originating from lipids vibrations were observed in healthy individuals in comparison with cancer patients. Moreover, Partial Last Square (PLS), Principal Component Analysis (PCA) and Hierarchical Component Analysis (HCA) of Raman spectra indicate that the ranges between 800 cm-1 and 1800 cm-1, 3477 cm-1 -3322 cm-1 and 1394 cm-1 -1297 cm-1 allow to distinguish cancer patients from healthy ones. The obtained results showed, that Raman spectroscopy is a good candidate, to become in future one of the diagnostic tools of Cholangiocarcinoma.en_US
dc.identifier.citationDepciuch J, Parlinska-Wojtan M, Rahmi Serin K, Bulut H, Ulukaya E, Tarhan N, Guleken Z. Differential of cholangiocarcinoma disease using Raman spectroscopy combined with multivariate analysis. Spectrochim Acta A Mol Biomol Spectrosc. 2022 Feb 5;272:121006. Epub ahead of print.en_US
dc.identifier.doi10.1016/j.saa.2022.121006en_US
dc.identifier.scopus2-s2.0-85124194627en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.saa.2022.121006
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2488
dc.identifier.volume272en_US
dc.identifier.wosWOS:000779148800016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBulut, Huri
dc.institutionauthorUlukaya, Engin
dc.language.isoenen_US
dc.relation.ispartofSpectrochim Acta A Mol Biomol Spectroscen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCholangiocarcinoma Diseaseen_US
dc.subjectHCAen_US
dc.subjectMultivariate analysisen_US
dc.subjectPCAen_US
dc.subjectPLSen_US
dc.subjectRaman Spectroscopyen_US
dc.titleDifferential of cholangiocarcinoma disease using Raman spectroscopy combined with multivariate analysisen_US
dc.typeArticleen_US

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