Is there any association between urothelial carcinoma of the bladder and human papillomavirus? A case-control study

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dc.authoridMehmet Sarıer / 0000-0002-8656-7416en_US
dc.authoridMeltem Demir / 0000-0002-0836-8585
dc.authorscopusidMehmet Sarıer / 57193698943
dc.authorscopusidMeltem Demir / 56689396100
dc.authorwosidMehmet Sarıer / B-8589-2018
dc.authorwosidMeltem Demir / ERD-5630-2022
dc.contributor.authorSarıer, Mehmet
dc.contributor.authorSepin, Nevgun
dc.contributor.authorKeles, Yildiz
dc.contributor.authorImir, Levent
dc.contributor.authorEmek, Mestan
dc.contributor.authorDemir, Meltem
dc.contributor.authorKukul, Erdal
dc.contributor.authorSoylu, Ahmet
dc.date.accessioned2020-08-30T20:06:13Z
dc.date.available2020-08-30T20:06:13Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Diyaliz Bölümüen_US
dc.description.abstractObjectives: Human papillomavirus (HPV) is a well-known oncogenic virus associated with anogenital carcinomas. Despite the anatomical proximity of the bladder and the anogenital region, the relationship between HPV and urothelial carcinoma of the bladder (UCB) is still a controversial issue. This study aimed to test the urethral swabs and first-void urine samples of patients with UCB for HPV-Deoxyribonucleic acid (DNA) using polymerase chain reaction (PCR) assay and to compare the results with a control group. Materials and Methods: Sixty-nine patients who were diagnosed with UCB between January and December 2018 were included in this case-control study. Sixty-nine patients who visited the urology outpatient clinic for non-oncological reasons within the study period were designated as the control group. Urethral swab and first-void morning urine samples were collected from each patient. HPV-DNA presence was investigated using a PCR kit that can detect a total of 22 HPV genotypes, of which 18 are high-risk and 3 are low-risk genotypes. Results: The mean age of the patients included in the study was 63.2 +/- 12.6 years and the male to female ratio was 5.3. HPV-DNA was detected in 28.9% (20/69) of the patients in the case group and in 8.7% (6/69) of the patients in the control group. HPV-DNA positivity was significantly higher in the case group (OR 4.24; 95% CI 1.63-12.34). No statistically significant relationship was found between HPV-DNA positivity and tumor grade (p = 0.36). Conclusion: A statistically significant relationship exists between HPV infection and UCB, regardless of the tumor grade.en_US
dc.identifier.citationSarier, M., Sepin, N., Keles, Y., Imir, L., Emek, M., Demir, M., ... & Soylu, A. (2020). Is there any association between urothelial carcinoma of the bladder and human papillomavirus? A case-control study. Urologia Internationalis, 104(1-2), 80-85.en_US
dc.identifier.doi10.1159/000500467en_US
dc.identifier.endpage86en_US
dc.identifier.issn0042-1138en_US
dc.identifier.issn1423-0399en_US
dc.identifier.pmid31067561en_US
dc.identifier.scopus2-s2.0-85065613120en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://doi.org/10.1159/000500467
dc.identifier.urihttps://hdl.handle.net/20.500.12713/426
dc.identifier.volume104en_US
dc.identifier.wosWOS:000526914900013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSarıer, Mehmeten_US
dc.institutionauthorDemir, Meltemen_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofUrologia Internationalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHuman Papillomavirusen_US
dc.subjectUrothelial Carcinoma Of The Bladderen_US
dc.subjectPolymerase Chain Reactionen_US
dc.titleIs there any association between urothelial carcinoma of the bladder and human papillomavirus? A case-control studyen_US
dc.typeArticleen_US

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