Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472
dc.authoridMerve Erkısa Genel / 0000-0002-3127-742X
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidMerve Erkısa Genel / 57126208900
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.authorwosidMerve Erkısa Genel / AAM-1001-2020
dc.contributor.authorSavani, Samira
dc.contributor.authorOnbaşlı, Kübra
dc.contributor.authorGündüz, Eren
dc.contributor.authorAydındoğan, Eda
dc.contributor.authorErkısa, Merve
dc.contributor.authorMuti, Abdullah
dc.contributor.authorKhan, Minahil
dc.contributor.authorSennaroglu, Alphan
dc.contributor.authorUlukaya, Engin
dc.contributor.authorYağcı Acar, Havva
dc.contributor.authorKölemen, Safacan
dc.date.accessioned2022-03-24T08:15:58Z
dc.date.available2022-03-24T08:15:58Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description.abstractA cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image-guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and activated its singlet oxygen generation as well as photothermal conversion potentials upon reacting with Cys. The laser irradiation of Cl-Cys induced significant cell death in cancer cells with high Cys level, while it stayed deactivated and non-emissive in a healthy cell line. A profound synergistic PDT/PTT effect was observed at high doses. Remarkably, Cl-Cys marks the first ever example of Cys-responsive small organic-based therapeutic agent and holds a great promise to develop new activity-based photosensitizers for dual phototherapy action.en_US
dc.identifier.citationSavani S, Onbasli K, Gunduz H, Aydındogan E, Erkısa M, Muti A, Khan M, Sennaroglu A, Ulukaya E, Yagci Acar H, Kolemen S. Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy. Bioorg Chem. 2022 Mar 17;122:105725.en_US
dc.identifier.doi10.1016/j.bioorg.2022.105725en_US
dc.identifier.pmid35316664en_US
dc.identifier.scopus2-s2.0-85126525592en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2022.105725
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2583
dc.identifier.wosWOS:000788718500004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErkısa Genel, Merve
dc.institutionauthorUlukaya, Engin
dc.language.isoenen_US
dc.relation.ispartofBioorg Chemen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectCysteineen_US
dc.subjectHemicyanineen_US
dc.subjectPhotosensitizersen_US
dc.subjectPhototherapyen_US
dc.subjectTheranosticsen_US
dc.titleDevelopment of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapyen_US
dc.typeArticleen_US

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