New gene expression regulators: long non-coding RNAs

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dc.authoridElif Karlık / 0000-0003-0669-2725en_US
dc.authoridNermin Gözükırmızı / 0000-0002-7129-3045
dc.authorscopusidElif Karlık / 56926577900
dc.authorscopusidNermin Gözükırmızı / 6701520637
dc.authorwosidElif Karlık / N-6348-2018
dc.authorwosidNermin Gözükırmızı / M-1419-2013
dc.contributor.authorGözükırmızı, Nermin
dc.contributor.authorKarlık, Elif
dc.date.accessioned2020-08-30T20:07:00Z
dc.date.available2020-08-30T20:07:00Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description2nd International Conference on Biosciences and Medical Engineering (ICBME) - Towards Innovative Research and Cross-Disciplinary Collaborations -- APR 11-12, 2019 -- Bali, INDONESIAen_US
dc.description.abstractLong non-coding RNAs (lncRNAs) play key roles in the regulation of biological processes including response to environmental stresses either transcriptional or post-transcriptional levels. The salinity tolerance of barley may play an important role in understanding the salinity mechanism. The aim of this study is the investigation of molecular responses of four barley genotypes Hordeum vulgare L. (Hasat, Beysehir 99, Konevi 98 and Tarm 92) to 150 mM salinity during 3 days of germination period. To reveal the effect of lncRNAs, we performed Real-time PCR and fluorescence in situ hybridization (FISH) studies. Study demonstrated salinity affected the expression levels of four lncRNAs, CNT0018772, CNT0031477, AK363461, and AK370506, during germination. Previous studies have shown that there was no statistical difference between barley varieties for expression level of CNT0018772 (p>0.05). However, our study indicated that there was statistically significant difference between barley varieties for CNT0031477 (p<0.05). Additionally, there was statistically significant difference between barley varieties for the two barley lncRNAs of AK363461 and AK370506, (p<0.05). We were also able to observe the localization of these four lncRNAs on barley chromosomes, which were exhibited under confocal microscope via in situ hybridization on barley root preparations. This study further supports the reasons why nowadays, lncRNAs are considered as major regulators.en_US
dc.description.sponsorshipPulau Pinang, Selangor, Melaka & Kedah of Malaysia, Yayasan FELDA, ADABI, ACS, Malaysia Chapter, Univ Teknologi Malaysia, Udayana Univen_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul UniversityIstanbul University [FDK-2016-23086]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Coordination Unit of Istanbul University (Project numbers: FDK-2016-23086).en_US
dc.identifier.citationGozukirmizi, N., & Karlik, E. (2019). New Gene Expression Regulators: Long Non-coding RNAs. In Mahat, NA and AbWahab, R and Huyop, FZ and Keyon, ASA and Attan, NB and Chandren, S (Ed.), PROCEEDINGS OF THE 2ND INTERNATIONAL CONFERENCE ON BIOSCIENCES AND MEDICAL ENGINEERING (ICBME2019): TOWARDS INNOVATIVE RESEARCH AND CROSS-DISCIPLINARY COLLABORATIONS. https://doi.org/10.1063/1.5125523en_US
dc.identifier.doi10.1063/1.5125523en_US
dc.identifier.isbn978-0-7354-1900-1
dc.identifier.issn0094-243Xen_US
dc.identifier.scopus2-s2.0-85072608180en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1063/1.5125523
dc.identifier.urihttps://hdl.handle.net/20.500.12713/673
dc.identifier.volume2155en_US
dc.identifier.wosWOS:000521596900019en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGözükırmızı, Nerminen_US
dc.institutionauthorKarlık, Elifen_US
dc.language.isoenen_US
dc.publisherAmer Inst Physicsen_US
dc.relation.ispartofProceedings of The 2nd International Conference On Biosciences and Medical Engineering (Icbme2019): Towards Innovative Research and Cross-Disciplinary Collaborationsen_US
dc.relation.ispartofseriesAIP Conference Proceedings
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleNew gene expression regulators: long non-coding RNAsen_US
dc.typeConference Objecten_US

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