The pivotal role of the gut microbiome in colorectal cancer

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dc.authoridRuqaiyyah Siddiqui / 0000-0001-9646-6208
dc.authoridNaveed Ahmed Khan / 0000-0001-7667-8553
dc.authorscopusidRuqaiyyah Siddiqui / 18635417000en_US
dc.authorscopusidNaveed Ahmed Khan / 7401797675en_US
dc.authorwosidRuqaiyyah Siddiqui / FVT-1496-2022en_US
dc.authorwosidNaveed Ahmed Khan / FXL-5617-2022en_US
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.contributor.authorBoghossian, Anania
dc.contributor.authorAlharbi, Ahmad M
dc.contributor.authorAlfahemi, Hasan
dc.contributor.authorKhan, Naveed Ahmed
dc.date.accessioned2022-12-08T08:28:24Z
dc.date.available2022-12-08T08:28:24Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractColorectal cancer is the third most diagnosed cancer worldwide and the second most prevalent cause of cancer-related mortality. It is believed that alterations within the gut microbiome may impact the development and progression of cancer. Additionally, the diet an individual maintains and the amount of alcohol consumed can alter the microbiome, thus impacting the development of colorectal cancer. A diet focused on fiber intake is considered beneficial, as it contains short-chain fatty acids such as butyrate, which have antitumor properties. Furthermore, current treatment strategies, such as chemotherapy, have various side effects. In this review, we discuss the role of the gut microbiome and oral bacteria in relation to colorectal cancer. We also deliberate on the role of diet and alcohol consumption in the development of colorectal cancer. Moreover, the influence of the various metabolites within the gut and the importance of gut inflammation in the development of colorectal cancer are explained. Finally, potential therapies such as fecal microbiota transfer and post/prebiotics are elaborated on. To further comprehend risk factors in the development of colorectal cancer, future studies are warranted to determine the precise mechanisms of action between the gut microbiome and carcinogenesis in order to develop therapies that may target gut microbial dysbiosis.en_US
dc.identifier.citationSiddiqui R, Boghossian A, Alharbi AM, Alfahemi H, Khan NA. The Pivotal Role of the Gut Microbiome in Colorectal Cancer. Biology (Basel). 2022 Nov 9;11(11):1642. doi: 10.3390/biology11111642. PMID: 36358343.en_US
dc.identifier.doi10.3390/biology11111642en_US
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85141777737en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.3390/biology11111642
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3435
dc.identifier.volume11en_US
dc.identifier.wosWOS:000880967500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSiddiqui, Ruqaiyyah
dc.institutionauthorKhan, Naveed Ahmed
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofBiologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcolorectal Canceren_US
dc.subjectDysbiosisen_US
dc.subjectFecal Microbiota Transferen_US
dc.subjectMicrobiomeen_US
dc.subjectPostbioticsen_US
dc.subjectPrebioticsen_US
dc.titleThe pivotal role of the gut microbiome in colorectal canceren_US
dc.typeReview Articleen_US

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