Functional recovery after wharton's jelly-derived mesenchymal stem cell administration in a patient with traumatic brain injury: a pilot study

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dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorwosidErdal Karaöz / IXE-6677-2023
dc.contributor.authorKabataş, Serdar
dc.contributor.authorCivelek, Erdinç
dc.contributor.authorSezen, Gülseli Berivan
dc.contributor.authorKaplan, Necati
dc.contributor.authorSavrunlu, Eyüp Can
dc.contributor.authorÇetin, Ercan
dc.contributor.authorDiren, Furkan
dc.contributor.authorKaraöz, Erdal
dc.date.accessioned2020-12-15T11:43:17Z
dc.date.available2020-12-15T11:43:17Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAIM: To introduce a traumatic brain injury (TBI) patient who underwent stem cell transplantation (SCT) in order to minimize the remaining injury deficiencies. MATERIAL and METHODS: This study included a 29 years old male who had TBI resulting from a vehicle accident which took place one and a half years ago. The participant received six doses of intrathecal, intramuscular, and intravenous transplantation of Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) at a goal dose of 1 x10(6) / kg respectively for each route of administration for six months. RESULTS: No important negative effects were reported. The patients' speech, cognitive, memory and fine motor skills were improved. The efficacy of treatment with SCT was assessed with cranial magnetic resonance imaging (MRI), computed tomography (CT) screening, and electroencephalography (EEG). CONCLUSION: SCT can have a promising future as a medical approach in recurrent TBI.en_US
dc.description.abstractAIM: To introduce a traumatic brain injury (TBI) patient who underwent stem cell transplantation (SCT) in order to minimize the remaining injury deficiencies. MATERIAL and METHODS: This study included a 29 years old male who had TBI resulting from a vehicle accident which took place one and a half years ago. The participant received six doses of intrathecal, intramuscular, and intravenous transplantation of Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) at a goal dose of 1 x10(6) / kg respectively for each route of administration for six months. RESULTS: No important negative effects were reported. The patients' speech, cognitive, memory and fine motor skills were improved. The efficacy of treatment with SCT was assessed with cranial magnetic resonance imaging (MRI), computed tomography (CT) screening, and electroencephalography (EEG). CONCLUSION: SCT can have a promising future as a medical approach in recurrent TBI.en_US
dc.identifier.citationKABATAS, S., Cİvelek, E., SEZEN, G. B., Kaplan, N., SAVRUNLU, E. C., Çetİn, E., ... & KARAOZ, E. (2020). Functional Recovery After Wharton’s Jelly-Derived Mesenchymal Stem Cell Administration in a Patient with Traumatic Brain Injury: A Pilot Study. Turkish Neurosurgery, 30(6).en_US
dc.identifier.doi10.5137/1019-5149.JTN.31732-20.1en_US
dc.identifier.endpage922en_US
dc.identifier.issn1019-5149en_US
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85098974007en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage914en_US
dc.identifier.trdizinid409794en_US
dc.identifier.urihttps://www.doi.org/10.5137/1019-5149.JTN.31732-20.1
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1274
dc.identifier.volume30en_US
dc.identifier.wosWOS:000593272300017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKaraöz, Erdal
dc.language.isoenen_US
dc.publisherTURKISH NEUROSURGICAL SOCen_US
dc.relation.ispartofTURKISH NEUROSURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStem Cellen_US
dc.subjectStem Cellen_US
dc.subjectBrain Injuryen_US
dc.subjectBrain Injuryen_US
dc.subjectUmbilical Corden_US
dc.subjectUmbilical Corden_US
dc.subjectTransplantationen_US
dc.subjectTransplantationen_US
dc.titleFunctional recovery after wharton's jelly-derived mesenchymal stem cell administration in a patient with traumatic brain injury: a pilot studyen_US
dc.typeArticleen_US

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