Advances in aptamer-based drug delivery vehicles for cancer therapy

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorGhasemi, Kousar
dc.contributor.authorDarroudi, Mahdieh
dc.contributor.authorRahimmanesh, Ilnaz
dc.contributor.authorGhomi, Matineh
dc.contributor.authorHassanpour, Mahnaz
dc.contributor.authorSharifi, Esmaeel
dc.contributor.authorYousefiasl, Satar
dc.contributor.authorAhmadi, Sepideh
dc.contributor.authorZarrabi, Ali
dc.contributor.authorBorzacchiello, Assunta
dc.contributor.authorRabiee, Mohammad
dc.contributor.authorPaiva-Santos, Ana Cláudia
dc.contributor.authorRabiee, Navid
dc.date.accessioned2022-08-17T06:38:21Z
dc.date.available2022-08-17T06:38:21Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractOverall, aptamers are special classes of nucleic acid-based macromolecules that are beginning to investigate because of their capability of avidity binding to a specific target for clinical use. Taking advantage of target-specific medicine led to more effective therapeutic and limitation of side effects of drugs. Herein, we discuss several aptamers and their binding capability and capacity for selecting tumor biomarkers and usage of them as targeting ligands for the functionalization of nanomaterials. We review recent applications based on aptamers and several nanoparticles to rise efficacy and develop carrier systems such as graphene oxide, folic acid, gold, mesopores silica, and various polymers and copolymer, polyethylene glycol, cyclodextrin, chitosan. The nanocarriers have been characterized by particle size, zeta potential, aptamer conjugation, and drug encapsulation efficiency. Hydrodynamic diameter and Zeta potential can used in order to monitor aptamers' crosslinking, in-vitro drug release, intracellular delivery of nanocarriers, and cellular cytotoxicity assay. Also, they are studied for cellular uptake and internalization to types of cancer cell lines such as colorectal, breast, prostate, leukemia and etc. The results are investigated in in-vivo cytotoxicity assay and cell viability assay. Targeted cancer therapy seems a good and promising strategy to overcome the systemic toxicity of chemotherapy.en_US
dc.identifier.citationGhasemii K, Darroudi M, Rahimmanesh I, Ghomi M, Hassanpour M, Sharifi E, Yousefiasl S, Ahmadi S, Zarrabi A, Borzacchiello A, Rabiee M, Paiva-Santos AC, Rabiee N. Advances in aptamer-based drug delivery vehicles for cancer therapy. Biomater Adv. 2022 Aug 5;140:213077. doi: 10.1016/j.bioadv.2022.213077. Epub ahead of print. PMID: 35952549.en_US
dc.identifier.doi10.1016/j.bioadv.2022.213077en_US
dc.identifier.pmid35952549en_US
dc.identifier.scopus2-s2.0-85135689188en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttp://doi.org/10.1016/j.bioadv.2022.213077
dc.identifier.uri2772-9516
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3102
dc.identifier.wosWOS:000878033400006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBiomaterials Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAptameren_US
dc.subjectDrug Deliveryen_US
dc.subjectSurface Modificationen_US
dc.titleAdvances in aptamer-based drug delivery vehicles for cancer therapyen_US
dc.typeArticleen_US

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