Superparamagnetic iron oxide nanoparticles and curcumin equally promote neuronal branching morphogenesis in the absence of nerve growth factor in PC12 cells

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authoridAtefeh Zarepour / 0000-0002-0347-5840en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorscopusidAtefeh Zarepour / 56700291100en_US
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.authorwosidAtefeh Zarepour / AAH-9225-2020en_US
dc.contributor.authorZarei, Mahshid
dc.contributor.authorEsmaeili, Abolghasem
dc.contributor.authorZarrabi, Ali
dc.contributor.authorZarepour, Atefeh
dc.date.accessioned2023-01-26T12:53:03Z
dc.date.available2023-01-26T12:53:03Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractRegeneration of the damaged neurons in neurological disorders and returning their activities are two of the main purposes of neuromedicine. Combination use of specific nanoformulations with a therapeutic compound could be a good candidate for neuroregeneration applications. Accordingly, this research aims to utilize the combination of curcumin, as a neurogenesis agent, with dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) to evaluate their effects on PC12 cells? neuronal branching morphogenesis in the absence of nerve growth factor. Therefore, the effects of each component alone and in combination form on the cytotoxicity, neurogenesis, and neural branching morphogenesis were evaluated using MTT assay, immunofluorescence staining, and inverted microscopy, respectively. Results confirmed the effectiveness of the biocompatible iron oxide nanoparticles (with a size of about 100 nm) in improving the percentage of neural branching (p < 0.01) in PC12 cells. In addition, the combination use of these nanoparticles with curcumin could enhance the effect of curcumin on neurogenesis (p < 0.01). These results suggest that SPIONs in combination with curcumin could act as an inducing factor on PC12 neurogenesis in the absence of nerve growth factor and could offer a novel therapeutic approach to the treatment of neurodegenerative diseases. © 2022 by the authors.en_US
dc.identifier.citationZarei, M., Esmaeili, A., Zarrabi, A., & Zarepour, A. (2022). Superparamagnetic Iron Oxide Nanoparticles and Curcumin Equally Promote Neuronal Branching Morphogenesis in the Absence of Nerve Growth Factor in PC12 Cells. Pharmaceutics, 14(12), 2692.en_US
dc.identifier.doi10.3390/pharmaceutics14122692en_US
dc.identifier.issn1999-4923en_US
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85144891963en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://dx.doi.org/10.3390/pharmaceutics14122692
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3848
dc.identifier.volume14en_US
dc.identifier.wosWOS:000904236000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZarrabi, Ali
dc.institutionauthorZarepour, Atefeh
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCombination Therapyen_US
dc.subjectCurcuminen_US
dc.subjectNeuronal Branchingen_US
dc.subjectNeuroregeneration Neuritogenesisen_US
dc.subjectSuperparamagnetic Iron Oxide Nanoparticlesen_US
dc.titleSuperparamagnetic iron oxide nanoparticles and curcumin equally promote neuronal branching morphogenesis in the absence of nerve growth factor in PC12 cellsen_US
dc.typeArticleen_US

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