Gelatin methacryloyl/nanosilicate nanocomposite hydrogels encapsulating dexamethasone with a tunable crosslinking density for bone repair

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dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authoridZeynep Püren Akgüner / 57205403842
dc.authorscopusidAyça Bal Öztürk / 57062000100en_US
dc.authorscopusidZeynep Püren Akgüner / 57205403842
dc.authorwosidAyça Bal Öztürk / M-4472-2018en_US
dc.authorwosidZeynep Püren Akgüner / CBX-7589-2022
dc.contributor.authorAlarçin, Emine
dc.contributor.authorDokgöz, Ayşe Begüm
dc.contributor.authorAkgüner Püren, Zeynep
dc.contributor.authorSeki, Hatice Kübra
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2022-11-08T13:33:26Z
dc.date.available2022-11-08T13:33:26Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractDespite various strategies have been proposed to accelerate bone regeneration, the treatment of bone defects in critical size still remains a clinical challenge. In this study, we fabricated nanocomposite gelatin methacryloyl (GelMA)/nanosilicate (NS) hydrogels for the delivery of dexamethasone (DEX), and systematically investigated their performance in drug delivery for bone repair. Nanocomposite hydrogels were fabricated by mold casting, and exposed to ultraviolet (UV) light to induce covalent crosslinking. Afterwards, we conducted a systematic characterization study to determine the effects of varying NS concentration, GelMA methacrylation degree and UV exposure time on mechanical, structural, and drug release behaviors of nanocomposite hydrogels. In particular, the higher methacrylation degree of GelMA, longer UV exposure and the presence of NS exhibited gradually enhanced mechanical properties. For instance, the compressive strengths of nanocomposite hydrogels containing 0% (w/v) NS (G0NS120) and 3% (w/v) NS (G3NS120) at 120 s of UV exposure were 194.816 kPa–367.284 kPa (p < 0.001), respectively. Similarly, they exhibited higher swelling ratio (%) and slower degradation rate (%) with longer UV exposure and increased NS amount. Nanocomposite hydrogels revealed slower drug release rate due to longer UV exposure and increased NS amount. At day 14 of the release study, 99.53% and 60.687% of DEX were released from G0NS120 and G3NS120, respectively. Particularly, the nanocomposite GelMA/ NS hydrogels supported osteoblast adhesion well, and NS and DEX exhibited synergistic effect on osteoblast proliferation with 5.01 fold increase after 7 days of culture. Our results clearly showed that GelMA/NS nanocomposite hydrogels with tunable physiochemical and drug carrier properties could provide a favorable option for accelerating bone repair.en_US
dc.identifier.citationAlarçin, E., Dokgöz, A. B., Akgüner, Z. P., Seki, H. K., & Bal-Öztürk, A. (2022). Gelatin methacryloyl/nanosilicate nanocomposite hydrogels encapsulating dexamethasone with a tunable crosslinking density for bone repair. Journal of Drug Delivery Science and Technology, 77 doi:10.1016/j.jddst.2022.103844en_US
dc.identifier.doi10.1016/j.jddst.2022.103844en_US
dc.identifier.scopus2-s2.0-85139732315en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2022.103844
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3273
dc.identifier.volume77en_US
dc.identifier.wosWOS:000884846900004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBal Öztürk, Ayça
dc.language.isoenen_US
dc.publisherEditions de Santeen_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone Repairen_US
dc.subjectDexamethasoneen_US
dc.subjectGelMAen_US
dc.subjectNanocomposite Hydrogelsen_US
dc.subjectNanosilicateen_US
dc.titleGelatin methacryloyl/nanosilicate nanocomposite hydrogels encapsulating dexamethasone with a tunable crosslinking density for bone repairen_US
dc.typeArticleen_US

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