Estimated plasma volume is not a robust indicator of the severity of congestion in patients with heart failure

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dc.authoridGüvenç, Tolga Sinan/0000-0002-6738-266X
dc.authoridYILMAZ, Mehmet Birhan/0000-0002-8169-8628
dc.authoridVural, Mustafa Gökhan/0000-0002-7055-0492
dc.authoridBekar, Lutfu/0000-0002-3920-1382
dc.authorwosidGüvenç, Tolga Sinan/AAK-6020-2020
dc.authorwosidYILMAZ, Mehmet Birhan/Y-1372-2019
dc.authorwosidVural, Mustafa Gökhan/JEO-5899-2023
dc.authorwosidBekar, Lutfu/A-6945-2019
dc.contributor.authorGuvenc, Rengin Cetin
dc.contributor.authorGuvenc, Tolga Sinan
dc.contributor.authorAkil, Mehmet Ata
dc.contributor.authorBekar, Lutfu
dc.contributor.authorVural, Mustafa Gokhan
dc.contributor.authorYilmaz, Mehmet Birhan
dc.date.accessioned2024-05-19T14:42:18Z
dc.date.available2024-05-19T14:42:18Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: Congestion is the main cause of morbidity and a prime determinant of survival in patients with heart failure (HF). However, the assessment of congestion is subjective and estimation of plasma volume (ePV) has been suggested as a more objective measure of congestion. This study aimed to explore the relationships and interactions between ePV, the severity of congestion and survival using a nationwide registry.Methods: Of the 1054 patients with HF enrolled in the registry, 769 had sufficient data to calculate ePV (using the Duarte, Kaplan, and Hatrim equations) and relative plasma volume status (rPVS), and these patients were subsequently included in the present analysis. The severity of congestion was assessed using a 6-point congestion score (CS). Patients were divided into three groups according to the degree of congestion.Results: Out of four equations tested, only ePV(Duarte) and rPVS were statistically higher in patients with severe congestion as compared to patients with no congestion (p<0.001 for both). Both ePV(Duarte )(r = 0.197, p<0.001) and rPVS (r = 0.153, p<0.001) showed statistically significant correlations with CS and both had a modest accuracy (70.4% for ePV(Duarte )and 69.4% for rPVS) to predict a CS >= 3. After a median follow up of 496 days, both ePV(Duarte) (OR:1.14,95%CI:1.03-1.26, p = 0.01) and rPVS (OR:1.02, 95%CI:1.00-1.03, p = 0.03) were associated with all-cause mortality after adjusting for demo-graphic and clinical variables. However, none of the indices were associated with mortality following the introduction of CS to the models (p>0.05 for both).Conclusions: Elevated ePV(Duarte) and rPVS were indicators of congestion but with a limited robustness, and either parameter could be clinically useful when a comprehensive clinical evaluation of congestion is not feasible.en_US
dc.identifier.doi10.1016/j.amjms.2023.08.008
dc.identifier.endpage382en_US
dc.identifier.issn0002-9629
dc.identifier.issn1538-2990
dc.identifier.issue5en_US
dc.identifier.pmid37640264en_US
dc.identifier.scopus2-s2.0-85170245610en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage374en_US
dc.identifier.urihttps://doi.org10.1016/j.amjms.2023.08.008
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5226
dc.identifier.volume366en_US
dc.identifier.wosWOS:001097152900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAmerican Journal of the Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectHeart Failureen_US
dc.subjectPlasma Volumeen_US
dc.subjectCongestionen_US
dc.subjectMortalityen_US
dc.titleEstimated plasma volume is not a robust indicator of the severity of congestion in patients with heart failureen_US
dc.typeArticleen_US

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