Atrial fibrillation designation with micro-Raman spectroscopy and scanning acoustic microscope

dc.authoridŞeyma Parlatan / 0000-0003-2355-4674en_US
dc.authorscopusidŞeyma Parlatan / 57267804700en_US
dc.authorwosidŞeyma Parlatan / ABF-3308-2020
dc.contributor.authorParlatan, Uğur
dc.contributor.authorParlatan, Şeyma
dc.contributor.authorŞen, Kübra
dc.contributor.authorKeçoğlu, İbrahim
dc.contributor.authorUlukan, Mustafa Özer
dc.contributor.authorKarakaya, Atalay
dc.contributor.authorErkanlı, Korhan
dc.contributor.authorTürkoğlu, Halil
dc.contributor.authorUğurlucan, Murat
dc.contributor.authorÜnlü, Mehmet Burçin
dc.contributor.authorTanören, Bukem
dc.date.accessioned2022-05-20T07:21:54Z
dc.date.available2022-05-20T07:21:54Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Radyoterapi Bölümüen_US
dc.description.abstractAtrial fibrillation (AF) is diagnosed with the electrocardiogram, which is the gold standard in clinics. However, sufficient arrhythmia monitoring takes a long time, and many of the tests are made in only a few seconds, which can lead arrhythmia to be missed. Here, we propose a combined method to detect the effects of AF on atrial tissue. We characterize tissues obtained from patients with or without AF by scanning acoustic microscopy (SAM) and by Raman spectroscopy (RS) to construct a mechano-chemical profile. We classify the Raman spectral measurements of the tissue samples with an unsupervised clustering method, k-means and compare their chemical properties. Besides, we utilize scanning acoustic microscopy to compare and determine differences in acoustic impedance maps of the groups. We compared the clinical outcomes with our findings using a neural network classification for Raman measurements and ANOVA for SAM measurements. Consequently, we show that the stiffness profiles of the tissues, corresponding to the patients with chronic AF, without AF or who experienced postoperative AF, are in agreement with the lipid-collagen profiles obtained by the Raman spectral characterization. © 2022, The Author(s).en_US
dc.identifier.citationParlatan, U., Parlatan, S., Sen, K., Kecoglu, I., Ulukan, M. O., Karakaya, A., . . . Tanoren, B. (2022). Atrial fibrillation designation with micro-raman spectroscopy and scanning acoustic microscope. Scientific Reports, 12(1) doi:10.1038/s41598-022-10380-zen_US
dc.identifier.doi10.1038/s41598-022-10380-zen_US
dc.identifier.issn2045-2322en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85128435508en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-022-10380-z
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2674
dc.identifier.volume12en_US
dc.identifier.wosWOS:000783915800041en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorParlatan, Şeyma
dc.language.isoenen_US
dc.publisherNature Researchen_US
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAtrial fibrillation designation with micro-Raman spectroscopy and scanning acoustic microscopeen_US
dc.typeArticleen_US

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