Evaluation of 601 children with multisystem inflammatory syndrome (Turk MISC study)

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dc.authoridElmalı, Ferhan/0000-0002-1967-1811
dc.authoridEmiroğlu, Melike/0000-0003-1307-0246
dc.authoridGençeli, Mustafa/0000-0001-9455-2735
dc.authoridYesil, Edanur/0000-0002-8926-9959
dc.authoridtüter öz, şadiye kübra/0000-0002-2473-5672
dc.authoridTimurtaş Dayar, Gülperi/0000-0002-0547-5713
dc.authoridSahin, Irfan Oguz/0000-0003-0256-0653
dc.authorwosidElmalı, Ferhan/E-2943-2015
dc.authorwosidEmiroğlu, Melike/AAH-3566-2019
dc.authorwosidGençeli, Mustafa/JUU-4068-2023
dc.authorwosidHatipoglu, Nevin/IYS-6548-2023
dc.authorwosidYesil, Edanur/GSO-3630-2022
dc.authorwosidumit, zuhal/JXL-1538-2024
dc.authorwosidtüter öz, şadiye kübra/JXL-5907-2024
dc.contributor.authorYilmaz, Dilek
dc.contributor.authorKeles, Yildiz Ekemen
dc.contributor.authorEmiroglu, Melike
dc.contributor.authorDuramaz, Burcu Bursal
dc.contributor.authorUgur, Cuneyt
dc.contributor.authorKocabas, Bilge Aldemir
dc.contributor.authorCelik, Talyan
dc.date.accessioned2024-05-19T14:40:02Z
dc.date.available2024-05-19T14:40:02Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractPurpose Due to its link with the 2019 coronavirus, the multisystem inflammatory syndrome in children (MISC) has garnered considerable international interest. The aim of this study, in which MISC patients were evaluated multicenter, and the data of the third period of the Turk-MISC study group, to compare the clinical and laboratory characteristics and outcomes of MISC patients who did and did not require admission to an intensive care unit (ICU).Methods This retrospective multicenter observational study was carried out between June 11, 2021, and January 01, 2022. The demographics, complaints, laboratory results, system involvements, and outcomes of the patients were documented.Results A total of 601 patients were enrolled; 157 patients (26.1%) required hospitalization in the intensive care unit (ICU). Median age was 8 years (interquartile range (IQR) 4.5-11.3 years. The proportion of Kawasaki disease-like features in the ICU group was significantly higher than in the non-ICU group (56.1% vs. 43.2% p = 0.006). The ICU group had considerably lower counts of both lymphocytes and platelets (lymphocyte count 900 vs. 1280 cells x mu L, platelet count 153 vs. 212 cells x 10(3)/ mu L, all for p< 0.001). C-reactive protein, procalcitonin, and ferritin levels were significantly higher in the ICU group (CRP 164 vs. 129 mg/L, procalcitonin 9.2 vs. 2.2 mu g/L, ferritin 644 vs. 334 mu g/L, all for p< 0.001). Being between ages 5-12 and older than 12 increased the likelihood of hospitalization in the ICU by four [95% confidence intervals (CI)1.971-8.627] and six times (95% CI 2.575-14.654), respectively, compared to being between the ages 0-5. A one-unit increase in log d-dimer (mu g/L) and log troponin (ng/L) was also demonstrated to increase the need for intensive care by 1.8 (95% CI 1.079-3.233) and 1.4 times (95% CI 1.133-1.789), respectively. Conclusion: By comparing this study to our other studies, we found that the median age of MISC patients has been rising. Patients requiring an ICU stay had considerably higher levels of procalcitonin, CRP, and ferritin but significantly lower levels of lymphocyte and thrombocyte. In particular, high levels of procalcitonin in the serum might serve as a valuable laboratory marker for anticipating the need for intensive care.en_US
dc.description.sponsorshipWe express our sincere gratitude to all individuals and institutions who have contributed data to this study. Specifically, we recognize the authors and their respective laboratory for collecting the specimens. The sharing of genomic sequences and associaten_US
dc.description.sponsorshipWe express our sincere gratitude to all individuals and institutions who have contributed data to this study. Specifically, we recognize the authors and their respective laboratory for collecting the specimens. The sharing of genomic sequences and associated metadata through the GISAID Initiative on which this research is based.en_US
dc.identifier.doi10.1007/s00431-023-05207-6
dc.identifier.endpage5542en_US
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.issue12en_US
dc.identifier.pmid37782350en_US
dc.identifier.scopus2-s2.0-85173919954en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage5531en_US
dc.identifier.urihttps://doi.org10.1007/s00431-023-05207-6
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4895
dc.identifier.volume182en_US
dc.identifier.wosWOS:001081155800003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectChildrenen_US
dc.subjectMiscen_US
dc.subjectKawasaki Diseaseen_US
dc.subjectIntensive Care Uniten_US
dc.titleEvaluation of 601 children with multisystem inflammatory syndrome (Turk MISC study)en_US
dc.typeArticleen_US

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