Clinical features, diagnosis and treatment outcomes of Cushing's disease in children: A multicenter study

Basit Öğe Kaydı
dc.authoridEr, Eren/0000-0003-4770-0365
dc.authoridDündar, Bumin/0000-0002-7506-061X
dc.authoridEren, Erdal/0000-0002-1684-1053
dc.authoridTarcin, Gurkan/0000-0002-1874-7570
dc.authoridKara, Cengiz/0000-0002-8989-560X
dc.authorwosidEr, Eren/HNS-7811-2023
dc.authorwosidDündar, Bumin/JVE-1747-2024
dc.authorwosidEren, Erdal/JPK-3909-2023
dc.authorwosidTarcin, Gurkan/ABH-2180-2021
dc.contributor.authorTarcin, Gurkan
dc.contributor.authorCatli, Gonul
dc.contributor.authorCetinkaya, Semra
dc.contributor.authorEren, Erdal
dc.contributor.authorKardelen, Asli Derya
dc.contributor.authorAkinci, Aysehan
dc.contributor.authorBober, Ece
dc.date.accessioned2024-05-19T14:40:01Z
dc.date.available2024-05-19T14:40:01Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjective: Since Cushing's disease (CD) is less common in the paediatric age group than in adults, data on this subject are relatively limited in children. Herein, we aim to share the clinical, diagnostic and therapeutic features of paediatric CD cases.Design: National, multicenter and retrospective study.Patients: All centres were asked to complete a form including questions regarding initial complaints, physical examination findings, diagnostic tests, treatment modalities and follow-up data of the children with CD between December 2015 and March 2017.Measurements: Diagnostic tests of CD and tumour size.Results: Thirty-four patients (M:F = 16:18) from 15 tertiary centres were enroled. The most frequent complaint and physical examination finding were rapid weight gain, and round face with plethora, respectively. Late-night serum cortisol level was the most sensitive test for the diagnosis of hypercortisolism and morning adrenocorticotropic hormone (ACTH) level to demonstrate the pituitary origin (100% and 96.8%, respectively). Adenoma was detected on magnetic resonance imaging (MRI) in 70.5% of the patients. Transsphenoidal adenomectomy (TSA) was the most preferred treatment (78.1%). At follow-up, 6 (24%) of the patients who underwent TSA were reoperated due to recurrence or surgical failure.Conclusions: Herein, national data of the clinical experience on paediatric CD have been presented. Our findings highlight that presenting complaints may be subtle in children, the sensitivities of the diagnostic tests are very variable and require a careful interpretation, and MRI fails to detect adenoma in approximately one-third of cases. Finally, clinicians should be aware of the recurrence of the disease during the follow-up after surgery.en_US
dc.identifier.doi10.1111/cen.14980
dc.identifier.endpage28en_US
dc.identifier.issn0300-0664
dc.identifier.issn1365-2265
dc.identifier.issue1en_US
dc.identifier.pmid37814958en_US
dc.identifier.scopus2-s2.0-85173788943en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://doi.org10.1111/cen.14980
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4892
dc.identifier.volume100en_US
dc.identifier.wosWOS:001083355900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectChildrenen_US
dc.subjectCrooke's Hyaline Changeen_US
dc.subjectCushing's Diseaseen_US
dc.subjectHypercortisolismen_US
dc.subjectTranssphenoidal Adenomectomyen_US
dc.titleClinical features, diagnosis and treatment outcomes of Cushing's disease in children: A multicenter studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu