Graphene oxide nanoarchitectures in cancer biology: Nano-modulators of autophagy and apoptosis

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dc.authoridRen, Jun/0000-0002-0275-0783
dc.authoridDeldar-Abad-Paskeh, Mahshid/0000-0001-8976-6253
dc.authoridHamblin, Michael R/0000-0001-6431-4605
dc.authoridErtas, Yavuz Nuri/0000-0002-6791-7484
dc.authoridZandieh, Mohammad Arad/0000-0002-6048-3505
dc.authorwosidEntezari, Maliheh/JHT-4843-2023
dc.authorwosidRen, Jun/ACG-5366-2022
dc.authorwosidDeldar-Abad-Paskeh, Mahshid/HKW-4259-2023
dc.authorwosidHashemi, Mehrdad/JHT-4661-2023
dc.authorwosidMirzaei, Sepideh/AAB-1637-2022
dc.authorwosidren, jun/KHG-7717-2024
dc.authorwosidHamblin, Michael R/H-2758-2019
dc.contributor.authorTaheriazam, Afshin
dc.contributor.authorAbad, Ghazaleh Gholamiyan Yousef
dc.contributor.authorHajimazdarany, Shima
dc.contributor.authorImani, Mohammad Hassan
dc.contributor.authorZiaolhagh, Setayesh
dc.contributor.authorZandieh, Mohammad Arad
dc.contributor.authorBayanzadeh, Seyedeh Delaram
dc.date.accessioned2024-05-19T14:41:58Z
dc.date.available2024-05-19T14:41:58Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractNanotechnology is a growing field, with many potential biomedical applications of nanomedicine for the treatment of different diseases, particularly cancer, on the horizon. Graphene oxide (GO) nanoparticles can act as carbon-based nanocarriers with advantages such as a large surface area, good mechanical strength, and the capacity for surface modification. These nanostructures have been extensively used in cancer therapy for drug and gene delivery, photothermal therapy, overcoming chemotherapy resistance, and for imaging procedures. In the current review, we focus on the biological functions of GO nanoparticles as regulators of apoptosis and autophagy, the two major forms of programmed cell death. GO nanoparticles can either induce or inhibit autophagy in cancer cells, depending on the conditions. By stimulating autophagy, GO nanocarriers can promote the sensitivity of cancer cells to chemotherapy. However, by impairing autophagy flux, GO nanoparticles can reduce cell survival and enhance inflammation. Similarly, GO nanomaterials can increase ROS production and induce DNA damage, thereby sensitizing cancer cells to apoptosis. In vitro and in vivo experiments have investigated whether GO nanomaterials show any toxicity in major body organs, such as the brain, liver, spleen, and heart. Molecular pathways, such as ATG, MAPK, JNK, and Akt, can be regulated by GO nanomaterials, leading to effects on autophagy and apoptosis. These topics are discussed in this review to shed some lights towards the biomedical potential of GO nanoparticles and their biocompatibility, paving the way for their future application in clinical trials.en_US
dc.description.sponsorshipUS NIH [R01AI050875, R21AI121700]; 2232 International Fellowship for Outstanding Researchers Program of The Scientific and Technological Research Council of Turkiye (TUBITAK); [118C346]en_US
dc.description.sponsorshipMRH was supported by US NIH Grants R01AI050875 and R21AI121700. Y.N.E. acknowledges funding support from the 2232 International Fellowship for Outstanding Researchers Program of The Scientific and Technological Research Council of Turkiye (TUBITAK, Project No: 118C346) .en_US
dc.identifier.doi10.1016/j.jconrel.2023.01.028
dc.identifier.endpage522en_US
dc.identifier.issn0168-3659
dc.identifier.issn1873-4995
dc.identifier.pmid36641122en_US
dc.identifier.scopus2-s2.0-85146594891en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage503en_US
dc.identifier.urihttps://doi.org10.1016/j.jconrel.2023.01.028
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5184
dc.identifier.volume354en_US
dc.identifier.wosWOS:000963258200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Controlled Releaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectGraphene Oxideen_US
dc.subjectApoptosisen_US
dc.subjectAutophagyen_US
dc.subjectBiomedical Applicationsen_US
dc.subjectBiocompatibilityen_US
dc.subjectCancer Therapyen_US
dc.titleGraphene oxide nanoarchitectures in cancer biology: Nano-modulators of autophagy and apoptosisen_US
dc.typeReview Articleen_US

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