Clinical Characteristics of Children with Combined Pituitary Hormone Deficiency and the Effects of Growth Hormone Treatment

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dc.authoridacinikli, kubra yuksek/0000-0001-9492-4834
dc.authoridBesci, Özge/0000-0003-3135-9617
dc.authorwosidacinikli, kubra yuksek/GQP-1371-2022
dc.authorwosidBesci, Özge/HIR-3673-2022
dc.contributor.authorBesci, Ozge
dc.contributor.authorSevim, Reyhan Deveci
dc.contributor.authorAcinikli, Kubra Yuksek
dc.contributor.authorDemir, Korcan
dc.contributor.authorCatli, Gonul
dc.contributor.authorOzhan, Bayram
dc.contributor.authorUnuvar, Tolga
dc.date.accessioned2024-05-19T14:42:02Z
dc.date.available2024-05-19T14:42:02Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAim We aimed to describe the clinical characteristics of patients with congenital combined pituitary hormone deficiency (CPHD) and evaluate the first-year growth responses of individuals with CPHD and isolated growth hormone deficiency (IGHD) in order to establish the influence of other hormone deficiencies on growth response.Patients and Methods This retrospective study was conducted in four tertiary care centers in Turkey. The records of patients diagnosed with CPHD (n=39) and severe IGHD (n=50) were collected. Cases with acquired lesions or chronic diseases were not included in the study. Data are presented as median (interquartile range).Results Among 39 patients (13 females; 33%) with a diagnosis of CPHD, the majority of patients (64%) presented initially with combined deficits at baseline examination, whereas isolated deficiencies (36%) were less prevalent. Among all patients with GH deficiency, TSH, ACTH, FSH/LH, and ADH deficiencies were present in 94%, 74%, 44%, and 9% of patients, respectively. Patients with CPHD were diagnosed at a younger age (4.9 (8.4) vs. 11.6 (4.1), p<0.001, respectively) and had lower peak GH concentrations (0.4 (1.8) vs. 3.7 (2.9), p<0.001, respectively) than patients with IGHD. Patients with IGHD and CPHD had similar first-year growth responses (Delta height SD score of 0.55 (0.63) vs. 0.76 (0.71), respectively, p=0.45).Conclusions We established the nature and timing of numerous hormonal deficits emerging over time. We also identified that the existence of CPHD did not hinder growth response.en_US
dc.identifier.doi10.1055/a-2186-9304
dc.identifier.issn0300-8630
dc.identifier.issn1439-3824
dc.identifier.pmid38049102en_US
dc.identifier.scopus2-s2.0-85179719415en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org10.1055/a-2186-9304
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5193
dc.identifier.wosWOS:001113747500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofKlinische Padiatrieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectGrowth Hormoneen_US
dc.subjectCombined Pituitary Hormone Deficiencyen_US
dc.subjectMultiple Pituitary Hormone Deficiencyen_US
dc.subjectProp1en_US
dc.subjectChd7en_US
dc.titleClinical Characteristics of Children with Combined Pituitary Hormone Deficiency and the Effects of Growth Hormone Treatmenten_US
dc.typeArticleen_US

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