Cinnamic acid and lactobionic acid based nanoformulations as a potential antiamoebic therapeutics

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dc.authoridSiddiqui, Ruqaiyyah/0000-0001-9646-6208
dc.authoridKhan, Naveed/0000-0001-7667-8553
dc.authoridJabri, tooba/0000-0001-5889-0913
dc.authoridAkbar, Noor/0000-0002-8114-1969
dc.authorwosidShah, Muhammad Raza/AAR-3981-2021
dc.authorwosidKhan, Naveed/KCK-0156-2024
dc.authorwosidSiddiqui, Ruqaiyyah/AIF-2100-2022
dc.authorwosidKhan, Naveed/AAM-2892-2021
dc.contributor.authorAkbar, Noor
dc.contributor.authorKawish, Muhammad
dc.contributor.authorJabri, Tooba
dc.contributor.authorKhan, Naveed Ahmed
dc.contributor.authorShah, Muhammad Raza
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.date.accessioned2024-05-19T14:38:46Z
dc.date.available2024-05-19T14:38:46Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAcanthamoeba castellanii causes granulomatous amoebic encephalitis, an uncommon but severe brain infection and sight-threatening Acanthamoeba keratitis. Most of the currently used anti-amoebic treatments are not always effective, due to persistence of the cyst stage, and recurrence can occur. Here in this study we synthesize cin-namic acid and lactobionic acid-based magnetic nanoparticles (MNPs) using co-precipitation technique. These nanoformulations were characterized by Fourier transform infrared spectroscopy and Atomic form microscopy. The drugs alone (Hesperidin, Curcumin and Amphotericin B), magnetic NPs alone, and drug-loaded nano -for-mulations were evaluated at a concentration of 100 mu g/mL for antiamoebic activity against a clinical isolate of A. castellanii. Amoebicidal assays revealed that drugs and conjugation of drugs and NPs further enhanced amoebicidal effects of drug-loaded nanoformulations. Drugs and drug-loaded nanoformulations inhibited both encystation and excystation of amoebae. In addition, drugs and drug-loaded nanoformulations inhibited parasite binding capability to the host cells. Neither drugs nor drug-loaded nanoformulations showed cytotoxic effects against host cells and considerably reduced parasite-mediated host cell death. Overall, these findings imply that conjugation of medically approved drugs with MNPs produce potent anti-Acanthamoebic effects, which could eventually lead to the development of therapeutic medications.en_US
dc.description.sponsorshipAmerican University of Sharjah and the University of Sharjahen_US
dc.description.sponsorshipAuthors acknowledge the American University of Sharjah and the University of Sharjah for their support.en_US
dc.identifier.doi10.1016/j.exppara.2023.108474
dc.identifier.issn0014-4894
dc.identifier.issn1090-2449
dc.identifier.pmid36708943en_US
dc.identifier.scopus2-s2.0-85147294559en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1016/j.exppara.2023.108474
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4601
dc.identifier.volume246en_US
dc.identifier.wosWOS:000963596400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofExperimental Parasitologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAcanthamoeba Castellaniien_US
dc.subjectMagnetic Nanoparticlesen_US
dc.subjectHesperidinen_US
dc.subjectAmphotericin Ben_US
dc.subjectEncystationen_US
dc.subjectExcystationen_US
dc.subjectCytotoxicityen_US
dc.subjectCytopathogenicityen_US
dc.titleCinnamic acid and lactobionic acid based nanoformulations as a potential antiamoebic therapeuticsen_US
dc.typeArticleen_US

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