Topical application of metformin accelerates cutaneous wound healing in streptozotocin-induced diabetic rats

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dc.authoridFatma Kübra Tombultürk / 0000-0002-4358-2309en_US
dc.authorscopusidFatma Kübra Tombultürk / 56748052500
dc.authorwosidFatma Kübra Tombultürk / L-3969-2018
dc.contributor.authorTombultürk, Fatma Kübra
dc.contributor.authorTodurga-Seven, Zeynep Gizem
dc.contributor.authorHüseyinbaş, Önder
dc.contributor.authorÖzyazgan, Sibel
dc.contributor.authorTurgut, Ulutin
dc.contributor.authorKanigur-Sultuybek, Gönül
dc.date.accessioned2021-11-11T08:37:26Z
dc.date.available2021-11-11T08:37:26Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Bölümüen_US
dc.description.abstractBackground: Diabetic chronic wound, which is one of the diabetic complications caused by hyperglycemia, characterized by prolonged inflammation has become one of the most serious challenges in the clinic. Hyperglycemia during diabetes not only causes prolonged inflammation and delayed wound healing but also modulates the activation of nuclear factor-kappa B (NF-?B) and the expression of matrix metalloproteinases (MMPs). Although metformin is the oldest oral antihyperglycemic drug commonly used for treating type 2 diabetes, few studies have explored the molecular mechanism of its topical effect on wound healing. Therefore, we aimed to investigate the molecular effects of topical metformin application on delayed wound healing, which's common in diabetes. Methods and results: In this context, we created a full-thickness excisional wound model in Wistar albino rats and, investigated NF-?B p65 DNA-binding activity and expression levels of RELA (p65), MMP2 and MMP9 in wound samples taken on days 0, 3, 7, and 14 from diabetic/non-diabetic rats treated with metformin and saline. As a result of our study, we showed that topically applied metformin accelerates wound healing by suppressing NF-?B p65 activity and diminishing the expression of MMP2 and MMP9. Conclusions: Diabetic wounds treated with metformin healed even faster than those in the control group that mimicked standard wound healing.en_US
dc.identifier.citationTombulturk, F. K., Todurga-Seven, Z. G., Huseyinbas, O., Ozyazgan, S., Ulutin, T., & Kanigur-Sultuybek, G. (2021). Topical application of metformin accelerates cutaneous wound healing in streptozotocin-induced diabetic rats. Molecular biology reports, 10.1007/s11033-021-06843-7. Advance online publication.en_US
dc.identifier.doi10.1007/s11033-021-06843-7en_US
dc.identifier.pmid34718940en_US
dc.identifier.scopus2-s2.0-85118528121en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1007/s11033-021-06843-7
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2223
dc.identifier.wosWOS:000713081400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTombultürk, Fatma Kübra
dc.language.isoenen_US
dc.publisherSpringer Linken_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectMMPen_US
dc.subjectMetforminen_US
dc.subjectNF-kBen_US
dc.subjectWound Healingen_US
dc.titleTopical application of metformin accelerates cutaneous wound healing in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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