Chitosan: a versatile bio-platform for breast cancer theranostics

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dc.authoridAli Zarrabi / 0000-0003-0391-1769
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorMadamsetty, Vijay Sagar
dc.contributor.authorTavakol, Shima
dc.contributor.authorMoghassemi, Saeid
dc.contributor.authorDadashzadeh, Arezoo
dc.contributor.authorSchneible, John D.
dc.contributor.authorFatemi, Iman
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2022-01-19T13:42:15Z
dc.date.available2022-01-19T13:42:15Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractBreast cancer is considered one of the utmost neoplastic diseases globally, with a high death rate of patients. Over the last decades, many approaches have been studied to early diagnose and treat it, such as chemotherapy, hormone therapy, immunotherapy, and MRI and biomarker tests; do not show the optimal efficacy. These existing approaches are accompanied by severe side effects, thus recognizing these challenges, a great effort has been done to find out the new remedies for breast cancer. Main finding: Nanotechnology opened a new horizon to the treatment of breast cancer. Many nanoparticulate platforms for the diagnosis of involved biomarkers and delivering antineoplastic drugs are under either clinical trials or just approved by the Food and Drug Administration (FDA). It is well known that natural phytochemicals are successfully useful to treat breast cancer because these natural compounds are safer, available, cheaper, and have less toxic effects. Chitosan is a biocompatible and biodegradable polymer. Further, it has outstanding features, like chemical functional groups that can easily modify our interest with an exceptional choice of promising applications. Abundant studies were directed to assess the chitosan derivative-based nanoformulation's abilities in delivering varieties of drugs. However, the role of chitosan in diagnostics and theranostics not be obligated. The present servey will discuss the application of chitosan as an anticancer drug carrier such as tamoxifen, doxorubicin, paclitaxel, docetaxel, etc. and also, its role as a theranostics (i.e. photo-responsive and thermo-responsive) moieties. The therapeutic and theranostic potential of chitosan in cancer is promising and it seems that to have a good potential to get to the clinic.en_US
dc.identifier.citationMadamsetty, V. S., Tavakol, S., Moghassemi, S., Dadashzadeh, A., Schneible, J. D., Fatemi, I., ... & Kesharwani, P. (2021). Chitosan: A versatile bio-platform for breast cancer theranostics. Journal of Controlled Release.en_US
dc.identifier.doi10.1016/j.jconrel.2021.12.012en_US
dc.identifier.endpage752en_US
dc.identifier.issn0168-3659en_US
dc.identifier.issn1873-4995en_US
dc.identifier.pmid34906606en_US
dc.identifier.scopus2-s2.0-85121729351en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage733en_US
dc.identifier.urihttps://doi.org/10.1016/j.jconrel.2021.12.012
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2410
dc.identifier.volume341en_US
dc.identifier.wosWOS:000734880700005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofJOURNAL OF CONTROLLED RELEASEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChitosanen_US
dc.subjectBreast Canceren_US
dc.subjectDrug Deliveryen_US
dc.subjectNanoparticlesen_US
dc.subjectPhytochemicalsen_US
dc.subjectAnticancer Drugen_US
dc.titleChitosan: a versatile bio-platform for breast cancer theranosticsen_US
dc.typeReview Articleen_US

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