Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.contributor.authorTunç, Duygu
dc.contributor.authorDere, Egemen
dc.contributor.authorKarakaş, Didem
dc.contributor.authorCevatemre, Buse
dc.contributor.authorYılmaz, Veysel Turan
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2020-08-30T20:08:12Z
dc.date.available2020-08-30T20:08:12Z
dc.date.issued2017
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractMetal-based chemotherapeutics such as cisplatin are widely used treatment of lung cancer which is the major cause of cancer-related mortality worldwide. Recent studies demonstrated that novel metal-based compounds have strong cytotoxic activity in a similar way as cisplatin. Therefore, metal-based compounds have been synthesized and investigated in order to determine their cytotoxic activities. It has been also reported curcumin, which has been derived from turmeric plant, has powerful cytotoxic effect on various cancer cell lines. In the light of these data, it has been investigated the cytotoxic effects of combination of curcumin (0.78-100 mu M) and palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine [Pd(II) complex] (0.39-50 mu M) against non small lung cancer cell lines, A549 and H1299. It has been found that combination of Pd(II) complex and curcumin enhanced the cytotoxic activity and apoptotic cell death at 48 h, compared to single use of each agent, only in H1299 cell line (combination index <1). Apoptosis was evident by annexin v staining positivity, increased caspase 3/7 activity and the presence of pyknotic nuclei. Pro-apoptotic genes of TNFRSFIOA and HRK were found to be involved in apoptotic cell death. In conclusion, the application of this combination may be regarded as a novel and effective approach for the treatment of lung cancer due to its promising cytotoxic and apoptotic effect. (C) 2017 Elsevier Ltd. All rights reserved.en_US
dc.identifier.citationTunc, D., Dere, E., Karakas, D., Cevatemre, B., Yilmaz, V. T., & Ulukaya, E. (2017). Cytotoxic and apoptotic effects of the combination of palladium (II) 5, 5-diethylbarbiturate complex with bis (2-pyridylmethyl) amine and curcumin on non small lung cancer cell lines. Bioorganic & medicinal chemistry, 25(5), 1717-1723.en_US
dc.identifier.doi10.1016/j.bmc.2017.01.043en_US
dc.identifier.endpage1723en_US
dc.identifier.issn0968-0896en_US
dc.identifier.issn1464-3391en_US
dc.identifier.issue5en_US
dc.identifier.pmid28187956en_US
dc.identifier.scopus2-s2.0-85011586183en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1717en_US
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2017.01.043
dc.identifier.urihttps://hdl.handle.net/20.500.12713/902
dc.identifier.volume25en_US
dc.identifier.wosWOS:000395851500017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofBioorganic & Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMetal-Based Compoundsen_US
dc.subjectApoptosisen_US
dc.subjectDrug Therapyen_US
dc.subjectCurcuminen_US
dc.subjectNsclcen_US
dc.titleCytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell linesen_US
dc.typeArticleen_US

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