Can biomarkers predict myocardial iron overload in children with thalassemia major?

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dc.authoridGül Nihal Özdemir / 0000-0002-3204-4353en_US
dc.authoridTülin Tiraje Celkan / 0000-0001-7287-1276en_US
dc.authorscopusidGül Nihal Özdemir / 57208780173en_US
dc.authorscopusidTülin Tiraje Celkan / 57346781100en_US
dc.authorwosidGül Nihal Özdemir / GMN-1581-2022en_US
dc.authorwosidTülin Tiraje Celkan / FZB-3980-2022en_US
dc.contributor.authorKarakaş, Hasan
dc.contributor.authorEroğlu, Ayşe Güler
dc.contributor.authorAkyel, Nazlı Gülsüm
dc.contributor.authorÇiğ, Gülnaz
dc.contributor.authorAdaletli, İbrahim
dc.contributor.authorÖzdemir, Gül Nihal
dc.contributor.authorTürkkan, Emine
dc.contributor.authorCelkan, Tülin Tiraje
dc.date.accessioned2023-08-31T12:05:53Z
dc.date.available2023-08-31T12:05:53Z
dc.date.issued2023en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim:Beta-thalassemia major requires regular blood transfusions throughout life, which in turn leads to iron accumulation in the body. While cardiac T2* MRI is the gold standard in determining cardiac iron accumulation, it is not always feasible, which has led to the search for new biomarkers. Herein, the value of growth differentiation factor-15, galectin-3, and N-terminal pro-B-type natriuretic peptide in predicting cardiac iron accumulation is investigated in asymptomatic children with beta-thalassemia major. Materials and method:Forty-one patients aged 11-21 years and 41 age-, gender-, body mass index-matched healthy controls were included. Serum growth differentiation factor-15, galectin-3, and N-terminal pro-B-type natriuretic peptide levels were compared between the patients and controls. Additionally, the relations of these biomarkers with cardiac and liver T2 * MRI were investigated in the patients. Results:In the patients, growth differentiation factor-15, galectin-3, and N-terminal pro-B-type natriuretic peptide levels were higher than healthy controls (p < 0.001, p = 0.025, p < 0.001, respectively). There were no significant correlations of growth differentiation factor-15 and N-terminal pro-B-type natriuretic peptide levels with both cardiac and liver T2 * MRI measurements. While there was no significant correlation of serum galectin-3 with cardiac T2 * MRI measurements, a negative correlation was found with liver T2 * MRI measurements (p = 0.040, rho = -0.325). Conclusion:All three biomarkers investigated in this study failed to predict myocardial iron accumulation in asymptomatic children with beta-thalassemia major. However, a weak relation between serum galectin-3 level and hepatic iron accumulation was demonstrated.en_US
dc.identifier.citationKarakaş, H., Eroğlu, A. G., Akyel, N. G., Çığ, G., Adaletli, İ., Özdemir, G. N., ... & Celkan, T. T. (2023). Can biomarkers predict myocardial iron overload in children with thalassemia major?. Cardiology in the Young, 1-6.en_US
dc.identifier.doi10.1017/S1047951122004206en_US
dc.identifier.issn1047-9511en_US
dc.identifier.issn1467-1107en_US
dc.identifier.pmid36606531en_US
dc.identifier.scopus2-s2.0-85176969563en_US
dc.identifier.urihttp://dx.doi.org/10.1017/S1047951122004206
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3963
dc.identifier.wosWOS:000908301200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorÖzdemir, Gül Nihal
dc.institutionauthorCelkan, Tülin Tiraje
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofCardiology In The Youngen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGalectin-3en_US
dc.subjectGrowth Differentiation Factor-15en_US
dc.subjectIron Accumulationen_US
dc.subjectN-Terminal Pro-B-Type Natriuretic Peptideen_US
dc.subjectT2*MRIen_US
dc.subjectThalassemia Majoren_US
dc.titleCan biomarkers predict myocardial iron overload in children with thalassemia major?en_US
dc.typeArticleen_US

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