SERUM FETUIN-A AND RANKL LEVELS IN PATIENTS WITH EARLY STAGE BREAST CANCER

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dc.authoridNazli, Mehmet Ali/0000-0003-4605-7822;
dc.authorwosidNazli, Mehmet Ali/ABQ-9491-2022
dc.authorwosidkarabulut, senem/AAT-3594-2020
dc.contributor.authorAfsar, Cigdem Usul
dc.contributor.authorAral, Hale
dc.contributor.authorCan, Orcun
dc.contributor.authorTrabulus, Didem Can
dc.contributor.authorKaracetin, Didem
dc.contributor.authorNazli, Mehmet Ali
dc.contributor.authorGursu, Riza Umar
dc.date.accessioned2024-05-19T14:39:37Z
dc.date.available2024-05-19T14:39:37Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: Breast cancer (BC) is the primary cause of mortality due to cancer in females around the world. Fetuin-A is known to increase metastases over signals and peroxisomes related with growing. Receptor activator of nuclear factor-KB ligand (RANKL) takes part in cell adhesi-on, and RANKL inhibition is used in the management of cancer. We aimed to examine the relationship between serum fetuin-A, RANKL levels, other laboratory parameters and clinical findings in women diagnosed with early stage BC, in our population.Methods: Women having early stage BC (n=117) met our study inclusion criteria as they had no any anti-cancer the-rapy before. Thirty-seven healthy women controls were also confirmed with breast examination and ultrasonography and/or mammography according to their ages. Serum samples were stored at-80 & DEG;C and analysed via ELISA.Results: Median age of the patients was 53 (range: 57-86) while it was 47 (range: 23-74) in the healthy group. Patients had lower high-density lipoprotein levels (p=0.002) and higher neutrophil counts (p=0.014). Fetuin-A and RANKL levels did not differ between the gro-ups (p=0.116 and p=0.439, respectively) but RANKL leves were found to be lower in the favorable histological subtypes (p=0.04). Conclusions: In this study, we found no correlation between serum fetuin-A levels and clinical findings in patients diag-nosed with early stage BC. However, RANKL levels are found to be lower in subgroups with favorable histopatho-logic subtypes such as tubular, papillary and mucinous BC and there was statistically significant difference.en_US
dc.identifier.doi10.5937/jomb0-37386
dc.identifier.endpage257en_US
dc.identifier.issn1452-8258
dc.identifier.issn1452-8266
dc.identifier.issue2en_US
dc.identifier.pmid36987423en_US
dc.identifier.scopus2-s2.0-85153892516en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage249en_US
dc.identifier.urihttps://doi.org10.5937/jomb0-37386
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4817
dc.identifier.volume42en_US
dc.identifier.wosWOS:001044739400007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSoc Medical Biochemists Serbiaen_US
dc.relation.ispartofJournal of Medical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBreast Canceren_US
dc.subjectFetuin-Aen_US
dc.subjectRanklen_US
dc.subjectSerumen_US
dc.titleSERUM FETUIN-A AND RANKL LEVELS IN PATIENTS WITH EARLY STAGE BREAST CANCERen_US
dc.typeArticleen_US

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