Developing necrotizing enterocolitis: retrospective analysis of 1428 preterm infants at a level-III neonatal intensive care unit over a four years period

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dc.authoridMeltem Demir / 0000-0002-0836-8585en_US
dc.authoridHakan Ongun / 0000-0002-4671-4872
dc.authoridSelim Demirezen / 0000-0003-2834-641X
dc.authorscopusidMeltem Demir / 56689396100
dc.authorscopusidSelim Demirezen / 42061278400
dc.authorscopusidHakan Ongun / 8851884100
dc.authorwosidMeltem Demir / ERD-5630-2022
dc.authorwosidSelim Demirezen / EVK-7134-2022
dc.authorwosidHakan Ongun / AAP-8851-2021
dc.contributor.authorOngun, Hakan
dc.contributor.authorDemirezen, Selim
dc.contributor.authorDemir, Meltem
dc.date.accessioned2020-12-15T11:42:48Z
dc.date.available2020-12-15T11:42:48Z
dc.date.issued2020en_US
dc.departmentÄ°stinye Ãœniversitesi, Hastaneen_US
dc.description.abstractAim. To investigate NEC frequency in premature infants and assess risk factors associated with disease-onset and progression to intestinal perforation. Methods. Retrospective cohort in preterm neonates hospitalized between 2015 and 2018. Perinatal characteristics, clinical features, nutritional data and laboratory outcome were analyzed using SPSS-23 statistical package. Logistic regression was performed to analyze associated risk factors. Results. In 1428 neonates, the rate of developing NEC was 18.28 %. Conception with assisted reproductive technology, cesearean section and postnatal-steroids were associated with NEC (OR: 4.056, 95 % CI: 2.810-5.854, OR: 1.961, 95 % CI: 1.321-2.910, OR: 6.422; 95 % CI: 4.327-9.530). Timing of first enteral feeding was associated to developing NEC, but not to intestinal perforation (p < 0.001, p = 0.604). Forty-seven of 261 NEC patients (18 %) have developed intestinal perforation. Antenatal steroids showed to reduce severe consequences (p = 0.001). Timing of first enteral feeding and hemodynamically significant PDA were predisposing factors for NEC and low 5-minutes Apgar score for intestinal perforation. (OR: 6.515; 95 % CI: 5.011-8.470; OR: 4.715; 95 % CI: 2.717-8.183; OR: 2.748; 95 % CI: 1.100-6.866). Mortality was 9 %. Developing NEC increased risk of mortality by 2.192 times (95 % CI: 1.469- 3.271); in intestinal perforation, mortality risk increased to 11.527 (95 % CI: 6.293-21.115). Conclusion. NEC frequency was 18.28 %. Intestinal perforation occurred in 18 % of NEC patients. PDA and delay in first enteral nutrition were predisposing factors for acquiring NEC and low 5-minutes Apgar scores for intestinal perforation.en_US
dc.identifier.citationOngun, A. P. H., Demirezen, S., & Demir, A. P. M. (2020). Developing necrotizing enterocolitis: retrospective analysis of 1428 preterm infants at a level-III neonatal intensive care unit over a four years period. Arch Argent Pediatr, 118(6), 405-410.en_US
dc.identifier.doi10.5546/AAP.2020.ENG.405en_US
dc.identifier.endpage410en_US
dc.identifier.issn0325-0075en_US
dc.identifier.issue6en_US
dc.identifier.pmid33231048en_US
dc.identifier.scopus2-s2.0-85096728706en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage405en_US
dc.identifier.urihttps://www.doi.org/10.5546/AAP.2020.ENG.405
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1273
dc.identifier.volume118en_US
dc.identifier.wosWOS:000595311700009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOngun, Hakan
dc.institutionauthorDemirezen, Selim
dc.institutionauthorDemir, Meltem
dc.language.isoenen_US
dc.publisherSociedad Argentina de Pediatriaen_US
dc.relation.ispartofArchivos Argentinos de Pediatriaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApgar Scoreen_US
dc.subjectIntestinal Perforationen_US
dc.subjectNecrotizing Enterocolitisen_US
dc.subjectNutritionen_US
dc.subjectPremature Infanten_US
dc.titleDeveloping necrotizing enterocolitis: retrospective analysis of 1428 preterm infants at a level-III neonatal intensive care unit over a four years perioden_US
dc.typeArticleen_US

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