Long noncoding RNAs (lncRNAs) in pancreatic cancer progression
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Long noncoding RNAs (lncRNAs) are RNA molecules involved in gene regulation at transcriptional, post-transcriptional, and epigenetic levels. lncRNAs participate in regulating apoptosis and autophagy in pancreatic cancer (PCa) and can promote and/or decrease the proliferation rate of tumor cells. The metastasis of PCa cells is tightly regulated by lncRNAs and they can affect the mechanism of epithelial-mesenchymal transition (EMT) to modulate metastasis. The drug resistance of PCa cells, especially to gemcitabine, can be affected by lncRNAs. In addition, lncRNAs enriched in exosomes can be transferred among tumor cells to regulate their proliferation and metastasis. Antitumor compounds, such as curcumin and ginsenosides, can regulate lncRNA expression in PCa therapy. As we discuss here, the expression level of lncRNAs can be considered as both a diagnostic and prognostic tool in patients with PCa. Teaser: We discuss the role of long noncoding RNAs in the proliferation, invasion, and therapy response of pancreatic cancer cells, evaluating their prognostic and diagnostic functions in the clinical course of this disease.
Açıklama
Anahtar Kelimeler
Cancer Therapy, Chemoresistance, Invasion, IncRNA, MiRNA, Pancreatic Cancer
Kaynak
Drug Discovery Today
WoS Q DeÄŸeri
Q1
Scopus Q DeÄŸeri
Q1
Cilt
Sayı
Künye
Ashrafizadeh M, Rabiee N, Prem Kumar A, Sethi G, Zarrabi A, Wang Y. Long noncoding RNAs (lncRNAs) in pancreatic cancer progression. Drug Discov Today. 2022 May 16:S1359-6446(22)00202-1. doi: 10.1016/j.drudis.2022.05.012. Epub ahead of print. PMID: 35589014.
