Poly(L-lactic acid)/poly(ethylene oxide) based composite electrospun fibers loaded with magnesium-aluminum layered double hydroxide nanoparticles

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dc.authoridGökçe Erdemir / 0000-0002-6476-2421en_US
dc.authorscopusidGökçe Erdemir / 57207566355
dc.authorwosidGökçe Erdemir / AAS-4648-2021
dc.contributor.authorÖztürk, Esra Altay
dc.contributor.authorEge, Zeynep Rüya
dc.contributor.authorMurat, Semiha
dc.contributor.authorErdemir, Gökçe
dc.contributor.authorKuruca, Serap
dc.contributor.authorErkmen, Ziya Engin
dc.contributor.authorDuygulu, Özgür
dc.contributor.authorGündüz, Oğuzhan
dc.contributor.authorÇaykara, Tuncer
dc.contributor.authorEroğlu, Mehmet S
dc.date.accessioned2022-09-16T08:40:15Z
dc.date.available2022-09-16T08:40:15Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractTwo types of MgAl layered double hydroxide nanoparticles, MgAl LDH, at Mg:Al ratio of 2:1 and 3:1were prepared and used as inorganic fillers to improve the mechanical properties of poly(lactic acid)/poly(ethylene oxide) (PLA/PEO) electrospun composite fibers. Their detailed structural characterization was performed using X-ray diffraction (XRD) and transmission electron spectroscopy (TEM) techniques. Spectroscopic, thermal, mechanical, and morphological properties of the electrospun composite fibers, and cell proliferation on their surface, were examined. XRD and TEM analyses showed that the LDH nanoparticles were 50 nm in size and the Mg:Al ratio did not affect the average spacing between crystal layers. Fourier transform infrared (FTIR) and thermal analyses (TA) revealed the compatibility of the filler and the polymer matrix. The nanoparticles considerably improved the mechanical properties of the electrospun mats. The tensile strength and elongation at break values of the composite samples increased from 0.22 MPA to 0.40 MPa and 12.2 % to 45.66 %, respectively, resulting from the interaction between LDH and the polymer matrix. Scanning electron microscopy (SEM) and MTT analyses demonstrated that the electrospun composite fibers supported the SaOS-2 cells attachment and proliferation on the fiber surfaces, along with their suitable cytocompatibility.en_US
dc.identifier.citationOzturk EA, Ege ZR, Murat S, Erdemir G, Kuruca S, Erkmen ZE, Duygulu O, Gunduz O, Caykara T, Eroglu MS. Poly(L-lactic acid)/poly(ethylene oxide) based composite electrospun fibers loaded with magnesium-aluminum layered double hydroxide nanoparticles. Int J Biol Macromol. 2022 Sep 30;217:562-571. doi: 10.1016/j.ijbiomac.2022.07.055. Epub 2022 Jul 15. PMID: 35839957.en_US
dc.identifier.doi10.1016/j.ijbiomac.2022.07.055en_US
dc.identifier.issn0141-8130en_US
dc.identifier.pmid35839957en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://doi.org/10.1016/j.ijbiomac.2022.07.055
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3144
dc.identifier.wosWOS:000859709300006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErdemir, Gökçe
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMg-Al LDHen_US
dc.subjectPLAen_US
dc.subjectPLA/PEO Electrospun Maten_US
dc.titlePoly(L-lactic acid)/poly(ethylene oxide) based composite electrospun fibers loaded with magnesium-aluminum layered double hydroxide nanoparticlesen_US
dc.typeArticleen_US

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