Role of DNA repair genes XRCC3 and XRCC1 in predisposition to type 2 diabetes mellitus and diabetic nephropathy

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dc.authoridSemra Şardaş / 0000-0001-5456-8636en_US
dc.authorscopusidSemra Şardaş / 7003286974
dc.authorwosidSemra Şardaş / J-2175-2018
dc.contributor.authorYeşil-Devecioğlu, Tuğçe
dc.contributor.authorDayan, Akın
dc.contributor.authorDemirtunç, Refik
dc.contributor.authorŞardaş, Semra
dc.date.accessioned2020-08-30T20:06:59Z
dc.date.available2020-08-30T20:06:59Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.descriptionSardas, Semra/0000-0001-5456-8636; YesilDevecioglu, Tugce/0000-0002-7157-3442en_US
dc.description.abstractIntroduction: Increasing number of experimental and clinical studies suggest a strong relationship between hyperglycemia, oxidative stress, DNA damage and diabetic nephropathy (DN). Also, epidemiologic studies remark an enhanced risk of cancer with type 2 diabetes. This research aims to assess whether the X-ray cross complementing group 3 (XRCC3) gene T241M polymorphism (15861539) and X-ray cross complementing group 1 (XRCC1) gene A399G polymorphism (rs25487) are related with predisposition to type 2 diabetes mellitus (T2DM) and to diabetic nephropathy in Turkish population. Materials and methods: Polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) was performed to identify the distribution of genotypes and frequency of alleles of T241M polymorphism of the XRCC3 gene (XRCC3 T241M) and A399G polymorphism of the XRCC1 gene (XRCC1 A399G). The study population included 238 subjects residing in Istanbul, Turkey; 116 with T2DM, 50 with DN and 72 with normal glucose metabolism. Results and conclusion: Polymorphic Gln allele of XRCC1 gene was significantly related with T2DM and DN (OR 3.09, 95% CI 1.14-8.40 and OR 3.29 95% CI 1.23-8.80, respectively) however, there was no statistical association of XRCC3 T241M with T2DM or DN. The results of this study suggest that XRCC1 399Gln polymorphism is related with an increased susceptibility to T2DM and DN in the studied Turkish population. (C) 2018 SEEN y SED. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.description.sponsorshipResearch Foundation of Marmara UniversityMarmara University [SAG-C-DRP-100914-0320]en_US
dc.description.sponsorshipThis study was supported by Research Foundation of Marmara University [grant no. SAG-C-DRP-100914-0320].en_US
dc.identifier.citationYesil-Devecioglu, T., Dayan, A., Demirtunc, R., & Sardas, S. (2019). Role of DNA repair genes XRCC3 and XRCC1 in predisposition to type 2 diabetes mellitus and diabetic nephropathy. Endocrinologia, diabetes y nutricion, 66(2), 90-98.en_US
dc.identifier.doi10.1016/j.endinu.2018.08.010en_US
dc.identifier.endpage98en_US
dc.identifier.issn2530-0180en_US
dc.identifier.issue2en_US
dc.identifier.pmid30472145en_US
dc.identifier.scopus2-s2.0-85056876397en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage90en_US
dc.identifier.urihttps://doi.org/10.1016/j.endinu.2018.08.010
dc.identifier.urihttps://hdl.handle.net/20.500.12713/670
dc.identifier.volume66en_US
dc.identifier.wosWOS:000456689800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞardaş, Semraen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEndocrinologia Diabetes Y Nutricionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.subjectDiabetic Nephropathyen_US
dc.subjectXrcc3 T241men_US
dc.subjectRs861539en_US
dc.subjectXrcc1 A399gen_US
dc.subjectRs25487en_US
dc.titleRole of DNA repair genes XRCC3 and XRCC1 in predisposition to type 2 diabetes mellitus and diabetic nephropathyen_US
dc.typeArticleen_US

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