Light-induced hydrogels derived from poly(ethylene glycol) and acrylated methyl ricinoleate as biomaterials
Yükleniyor...
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley and Sons Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Hydrogels are hydrophilic crosslinked polymer networks that can absorb large amounts of water. They are used as biomaterials in numerous tissue engineering applications. Considering environmental awareness, the synthesis of biomaterials from renewable resources through green fabrication methods is essential. This study produces thermoresponsive hydrogels from a castor oil-based monomer, acrylated methyl ricinoleate, and poly(ethylene glycol) via an environmentally friendly synthesis method. A photopolymerization technique is used with a very short reaction time. Characterization of the hydrogels is performed using thermogravimetric analysis, scanning electron microscopy, and Fourier-transform infrared spectroscopy. Swelling and deswelling profiles are subsequently analyzed. A maximum equilibrium swelling degree of 271% is reached within 30 min. In vitro cytotoxicity assays of the hydrogels and the degradation products are performed to evaluate the biocompatibility. The hydrogels are biocompatible because the cell survival of all hydrogel samples and degradation products is greater than 100% and 85%, respectively. Consequently, the thermoresponsive hydrogels made from renewable raw materials in a green process offer interesting platforms for building biomaterials such as actuators for lab-on-a-chip devices, microfluidics, drug delivery systems, preclinical drug screening models, and regenerative medicine. © 2022 Wiley Periodicals LLC.
Açıklama
Anahtar Kelimeler
Acrylated Methyl Ricinoleate, Castor Oil, Environmentally Friendly Synthesis, Photopolymerization, Renewable Raw Materials, Thermoresponsive Hydrogels
Kaynak
Journal of Applied Polymer Science
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
Sayı
Künye
Cakir Hatir, P. (2022). Light-induced hydrogels derived from poly(ethylene glycol) and acrylated methyl ricinoleate as biomaterials. Journal of Applied Polymer Science, doi:10.1002/app.52754
