Light-induced hydrogels derived from poly(ethylene glycol) and acrylated methyl ricinoleate as biomaterials

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dc.authoridPınar Çakır Hatır / 0000-0002-3806-7118en_US
dc.authorscopusidPınar Çakır Hatır / 57203277694en_US
dc.authorwosidPınar Çakır Hatır / S-8707-2019
dc.contributor.authorÇakır Hatır, Pınar
dc.date.accessioned2022-06-24T06:11:38Z
dc.date.available2022-06-24T06:11:38Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractHydrogels are hydrophilic crosslinked polymer networks that can absorb large amounts of water. They are used as biomaterials in numerous tissue engineering applications. Considering environmental awareness, the synthesis of biomaterials from renewable resources through green fabrication methods is essential. This study produces thermoresponsive hydrogels from a castor oil-based monomer, acrylated methyl ricinoleate, and poly(ethylene glycol) via an environmentally friendly synthesis method. A photopolymerization technique is used with a very short reaction time. Characterization of the hydrogels is performed using thermogravimetric analysis, scanning electron microscopy, and Fourier-transform infrared spectroscopy. Swelling and deswelling profiles are subsequently analyzed. A maximum equilibrium swelling degree of 271% is reached within 30 min. In vitro cytotoxicity assays of the hydrogels and the degradation products are performed to evaluate the biocompatibility. The hydrogels are biocompatible because the cell survival of all hydrogel samples and degradation products is greater than 100% and 85%, respectively. Consequently, the thermoresponsive hydrogels made from renewable raw materials in a green process offer interesting platforms for building biomaterials such as actuators for lab-on-a-chip devices, microfluidics, drug delivery systems, preclinical drug screening models, and regenerative medicine. © 2022 Wiley Periodicals LLC.en_US
dc.identifier.citationCakir Hatir, P. (2022). Light-induced hydrogels derived from poly(ethylene glycol) and acrylated methyl ricinoleate as biomaterials. Journal of Applied Polymer Science, doi:10.1002/app.52754en_US
dc.identifier.doi10.1002/app.52754en_US
dc.identifier.issn0021-8995en_US
dc.identifier.scopus2-s2.0-85131860970en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/app.52754
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2933
dc.identifier.wosWOS:000811444100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofJournal of Applied Polymer Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylated Methyl Ricinoleateen_US
dc.subjectCastor Oilen_US
dc.subjectEnvironmentally Friendly Synthesisen_US
dc.subjectPhotopolymerizationen_US
dc.subjectRenewable Raw Materialsen_US
dc.subjectThermoresponsive Hydrogelsen_US
dc.titleLight-induced hydrogels derived from poly(ethylene glycol) and acrylated methyl ricinoleate as biomaterialsen_US
dc.typeArticleen_US

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