Mechanical characterization and torsional buckling of pediatric cardiovascular materials

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dc.authoridDONMAZOV, SAMIR/0000-0001-8814-3572
dc.authoridPiskin, Senol/0000-0002-8799-9472
dc.authorwosidDONMAZOV, SAMIR/JWA-6633-2024
dc.authorwosidPiskin, Senol/F-3741-2019
dc.contributor.authorDonmazov, Samir
dc.contributor.authorPiskin, Senol
dc.contributor.authorGolcez, Tansu
dc.contributor.authorKul, Demet
dc.contributor.authorArnaz, Ahmet
dc.contributor.authorPekkan, Kerem
dc.date.accessioned2024-05-19T14:40:22Z
dc.date.available2024-05-19T14:40:22Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractIn complex cardiovascular surgical reconstructions, conduit materials that avoid possible large-scale structural deformations should be considered. A fundamental mode of mechanical complication is torsional buckling which occurs at the anastomosis site due to the mechanical instability, leading surgical conduit/patch surface deformation. The objective of this study is to investigate the torsional buckling behavior of commonly used materials and to develop a practical method for estimating the critical buckling rotation angle under physiological intramural vessel pressures. For this task, mechanical tests of four clinically approved materials, expanded polytetrafluoroethylene (ePTFE), Dacron, porcine and bovine pericardia, commonly used in pediatric cardiovascular surgeries, are conducted (n = 6). Torsional buckling initiation tests with n = 4 for the baseline case (L = 7.5 cm) and n = 3 for the validation of ePTFE (L = 15 cm) and Dacron (L = 15 cm and L = 25 cm) for each are also conducted at low venous pressures. A practical predictive formulation for the buckling potential is proposed using experimental observations and available theory. The relationship between the critical buckling rotation angle and the lumen pressure is determined by balancing the circumferential component of the compressive principal stress with the shear stress generated by the modified critical buckling torque, where the modified critical buckling torque depends linearly on the lumen pressure. While the proposed technique successfully predicted the critical rotation angle values lying within two standard deviations of the mean in the baseline case for all four materials at all lumen pressures, it could reliably predict the critical buckling rotation angles for ePTFE and Dacron samples of length 15 cm with maximum relative errors of 31% and 38%, respectively, in the validation phase. However, the validation of the performance of the technique demonstrated lower accuracy for Dacron samples of length 25 cm at higher pressure levels of 12 mmHg and 15 mmHg. Applicable to all surgical materials, this formulation enables surgeons to assess the torsional buckling potential of vascular conduits noninvasively. Bovine pericardium has been found to exhibit the highest stability, while Dacron (the lowest) and porcine pericardium have been identified as the least stable with the (unitless) torsional buckling resistance constants, 43,800, 12,300 and 14,000, respectively. There was no significant difference between ePTFE and Dacron, and between porcine and bovine pericardia. However, both porcine and bovine pericardia were found to be statistically different from ePTFE and Dacron individually (p < 0.0001). ePTFE exhibited highly nonlinear behavior across the entire strain range [0, 0.1] (or 10% elongation). The significant differences among the surgical materials reported here require special care in conduit construction and anastomosis design.en_US
dc.description.sponsorshipEuropean Research Executive Agency Marie-Sklodowska Curie Actions - Individual Grant [966765, 101038096, TUBITAK ARDEB 1001 (122E470)]; European Research Council (ERC); European Research Council (ERC) [966765] Funding Source: European Research Council (ERC)en_US
dc.description.sponsorshipThis work is partially supported by the European Research Council (ERC) Proof of Concept Grant-BloodTurbine project #966765, European Research Executive Agency Marie-Sklodowska Curie Actions-Individual Grant No. (101038096), and TUBITAK ARDEB 1001 (122E470).en_US
dc.identifier.doi10.1007/s10237-023-01809-z
dc.identifier.issn1617-7959
dc.identifier.issn1617-7940
dc.identifier.pmid38361084en_US
dc.identifier.scopus2-s2.0-85185143163en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1007/s10237-023-01809-z
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4951
dc.identifier.wosWOS:001163167900003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofBiomechanics and Modeling In Mechanobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCongenital Heart Diseaseen_US
dc.subjectSurgical Patch Designen_US
dc.subjectTorsionen_US
dc.subjectVascular Mechanicsen_US
dc.subjectFontanen_US
dc.subjectConduiten_US
dc.subjectMaterial Characteristicsen_US
dc.subjectNonlinear Optimizationen_US
dc.subjectTissue Engineered Patchesen_US
dc.subjectPtfeen_US
dc.subjectPericardiumen_US
dc.titleMechanical characterization and torsional buckling of pediatric cardiovascular materialsen_US
dc.typeArticleen_US

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