A Comprehensive Study on Peppermint Oil and Cinnamon Oil as Nanoemulsion: Preparation, Stability, Cytotoxicity, Antimicrobial, Antifungal, and Antioxidant Activity

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dc.authoridadıgüzel, mehmet/0000-0002-2385-9649
dc.authoridTorkay, Gülşah/0000-0002-6803-494X
dc.authoridBARAN, Alper/0000-0002-3089-6624
dc.authoridALPARSLAN, LEVENT/0000-0003-0113-6850
dc.authoridBAL OZTURK, AYCA/0000-0002-6502-528X
dc.authorid, Emrah Ozakar/0000-0002-7443-208X
dc.authorid, Rukiye Sevinc Ozakar/0000-0002-2972-8084
dc.authorwosidadıgüzel, mehmet/JXY-7556-2024
dc.authorwosidTorkay, Gülşah/IUP-3797-2023
dc.authorwosidBAL OZTURK, AYCA/M-4472-2018
dc.contributor.authorOzakar, Emrah
dc.contributor.authorAlparslan, Levent
dc.contributor.authorAdiguzel, M. Cemal
dc.contributor.authorTorkay, Gulsah
dc.contributor.authorBaran, Alper
dc.contributor.authorBal-ozturk, Ayca
dc.contributor.authorSevinc-ozakar, Rukiye
dc.date.accessioned2024-05-19T14:40:06Z
dc.date.available2024-05-19T14:40:06Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground Recent studies have shown that nanoemulsions prepared with essential oils have significant antimicrobial potential against multidrug-resistant pathogens due to increased chemical stability. Nanoemulsion also promotes controlled and sustained release, which increases their bioavailability and efficacy against multidrug-resistant bacteria.Objective This study aimed to investigate the antimicrobial, antifungal, antioxidant, and cytotoxicity properties of cinnamon essential oil and peppermint essential oil as nanoemulsions compared to pure forms. For this purpose, analyses of the selected stable nanoemulsions were carried out.Methods The droplet sizes and zeta potentials of peppermint essential oil nanoemulsions and cinnamon essential oil nanoemulsions were found to be 154.6 +/- 1.42 nm and -17.1 +/- 0.68 mV and 200.3 +/- 4.71 nm and -20.0 +/- 0.81 mV, respectively. Although the amount of essential oil used in nanoemulsions was 25% w/w, antioxidant and antimicrobial activities were found to be more effective compared to pure essential oils.Results In cytotoxicity studies on the 3T3 cell line, both essential oil nanoemulsions showed higher cell viability than pure essential oils. At the same time, cinnamon essential oil nanoemulsions exhibited a higher antioxidant property than peppermint essential oil nanoemulsions and showed superiority in the antimicrobial susceptibility test conducted against four bacteria and two fungi. Cell viability tests determined that cinnamon essential oil nanoemulsions showed considerably higher cell viability compared to pure cinnamon essential oil.Conclusion These findings indicated that the prepared nanoemulsions in the current study might positively influence the dosing regimen and clinical outcomes of antibiotic therapy.en_US
dc.identifier.doi10.2174/1567201820666230612123011
dc.identifier.endpage622en_US
dc.identifier.issn1567-2018
dc.identifier.issn1875-5704
dc.identifier.issue4en_US
dc.identifier.pmid37309758en_US
dc.identifier.scopus2-s2.0-85177646961en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage603en_US
dc.identifier.urihttps://doi.org10.2174/1567201820666230612123011
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4906
dc.identifier.volume21en_US
dc.identifier.wosWOS:001138071900009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Drug Deliveryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCinnamon Oilen_US
dc.subjectPeppermint Oilen_US
dc.subjectNanoemulsionen_US
dc.subjectStabilityen_US
dc.subjectAntioxidanten_US
dc.subjectAntimicrobialen_US
dc.subjectCell Viabilityen_US
dc.titleA Comprehensive Study on Peppermint Oil and Cinnamon Oil as Nanoemulsion: Preparation, Stability, Cytotoxicity, Antimicrobial, Antifungal, and Antioxidant Activityen_US
dc.typeArticleen_US

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